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Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex

Eastwood, Justin R, Ribot, Raoul FH, Rollins, Lee Ann, Buchanan, Katherine L, Walder, Ken, Bennett, Andrew TD and Berg, Mathew L 2017, Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex, Scientific reports, vol. 7, pp. 1-11, doi: 10.1038/s41598-017-13476-z.

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Title Host heterozygosity and genotype rarity affect viral dynamics in an avian subspecies complex
Author(s) Eastwood, Justin R
Ribot, Raoul FHORCID iD for Ribot, Raoul FH orcid.org/0000-0003-3869-8873
Rollins, Lee AnnORCID iD for Rollins, Lee Ann orcid.org/0000-0002-3279-7005
Buchanan, Katherine LORCID iD for Buchanan, Katherine L orcid.org/0000-0002-6648-5819
Walder, KenORCID iD for Walder, Ken orcid.org/0000-0002-6758-4763
Bennett, Andrew TDORCID iD for Bennett, Andrew TD orcid.org/0000-0001-8512-2805
Berg, Mathew LORCID iD for Berg, Mathew L orcid.org/0000-0002-5774-3089
Journal name Scientific reports
Volume number 7
Article ID 13310
Start page 1
End page 11
Total pages 11
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2017-10
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Summary Genetic diversity at community, population and individual levels is thought to influence the spread of infectious disease. At the individual level, inbreeding and heterozygosity are associated with increased risk of infection and disease severity. Host genotype rarity may also reduce infection risk if pathogens are co-adapted to common or local hosts, but to date, no studies have investigated the relative importance of genotype rarity and heterozygosity for infection in a wild, sexually reproducing vertebrate. With beak and feather disease virus (BFDV) infection in a wild parrot (Platycercus elegans), we show that both heterozygosity and genotype rarity of individual hosts predicted infection, but in contrasting ways. Heterozygosity was negatively associated with probability of infection, but not with infection load. In contrast, increased host genotype rarity was associated with lower viral load in infected individuals, but did not predict infection probability. These effects were largely consistent across subspecies, but were not evident at the population level. Subspecies and age were also strongly associated with infection. Our study provides novel insights into infection dynamics by quantifying rarity and diversity simultaneously. We elucidate roles that host genetic diversity can play in infection dynamics, with implications for understanding population divergence, intraspecific diversity and conservation.
Language eng
DOI 10.1038/s41598-017-13476-z
Field of Research 060503 Microbial Genetics
070712 Veterinary Virology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103019

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.