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Effects of invasion history on physiological responses to immune system activation in invasive Australian cane toads

Selechnik, Daniel, West, Andrea J., Brown, Gregory P., Fanson, Kerry V., Addison, BriAnne, Rollins, Lee A. and Shine, Richard 2017, Effects of invasion history on physiological responses to immune system activation in invasive Australian cane toads, PeerJ, vol. 5, pp. 1-19, doi: 10.7717/peerj.3856.

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Title Effects of invasion history on physiological responses to immune system activation in invasive Australian cane toads
Author(s) Selechnik, Daniel
West, Andrea J.
Brown, Gregory P.
Fanson, Kerry V.ORCID iD for Fanson, Kerry V. orcid.org/0000-0001-9372-2018
Addison, BriAnne
Rollins, Lee A.ORCID iD for Rollins, Lee A. orcid.org/0000-0002-3279-7005
Shine, Richard
Journal name PeerJ
Volume number 5
Article ID e3856
Start page 1
End page 19
Total pages 19
Publisher PeerJ
Place of publication London, Eng.
Publication date 2017-10-06
ISSN 2167-8359
Keyword(s) Rhinella marina
eco-immunology
phagocytosis
cane toad
invasive species
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CORTICOSTERONE METABOLITE RESPONSES
RHINELLA-MARINA
URINARY CORTICOSTERONE
PERSONALITY-TRAITS
DISEASE VIRUS
BUFO-MARINUS
EVOLUTION
PERFORMANCE
INFECTION
Summary The cane toad (Rhinella marina) has undergone rapid evolution during its invasion of tropical Australia. Toads from invasion front populations (in Western Australia) have been reported to exhibit a stronger baseline phagocytic immune response than do conspecifics from range core populations (in Queensland). To explore this difference, we injected wild-caught toads from both areas with the experimental antigen lipopolysaccharide (LPS, to mimic bacterial infection) and measured whole-blood phagocytosis. Because the hypothalamic-pituitary-adrenal axis is stimulated by infection (and may influence immune responses), we measured glucocorticoid response through urinary corticosterone levels. Relative to injection of a control (phosphate-buffered saline), LPS injection increased both phagocytosis and the proportion of neutrophils in the blood. However, responses were similar in toads from both populations. This null result may reflect the ubiquity of bacterial risks across the toad’s invaded range; utilization of this immune pathway may not have altered during the process of invasion. LPS injection also induced a reduction in urinary corticosterone levels, perhaps as a result of chronic stress.
Language eng
DOI 10.7717/peerj.3856
Field of Research 060802 Animal Cell and Molecular Biology
060804 Animal Immunology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103264

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.