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A systematic review of maternal antidepressant use in pregnancy and short and long-term offspring's outcomes

Prady, Stephanie L, Hanlon, Inna, Fraser, Lorna K and Mikocka-Walus, Antonina 2018, A systematic review of maternal antidepressant use in pregnancy and short and long-term offspring's outcomes, Archives of Women's Mental Health, vol. 21, no. 2, pp. 127-140, doi: 10.1007/s00737-017-0780-3.

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Title A systematic review of maternal antidepressant use in pregnancy and short and long-term offspring's outcomes
Author(s) Prady, Stephanie L
Hanlon, Inna
Fraser, Lorna K
Mikocka-Walus, AntoninaORCID iD for Mikocka-Walus, Antonina orcid.org/0000-0003-4864-3956
Journal name Archives of Women's Mental Health
Volume number 21
Issue number 2
Start page 127
End page 140
Total pages 14
Publisher Springer Verlag
Place of publication Berlin, Germany
Publication date 2018-04
ISSN 1434-1816
Keyword(s) Antidepressants
Low birth weight
Neurobehaviour
Neurodevelopment
Pregnancy
Science & Technology
Life Sciences & Biomedicine
Psychiatry
SEROTONIN REUPTAKE INHIBITORS
PRENATAL EXPOSURE
META-ANALYSIS
DEPRESSION
RISK
CHILDREN
WOMEN
GROWTH
COHORT
PERIOD
Summary The relative safety of antidepressants during pregnancy has received substantial attention, but most syntheses fail to account for mental illness effects. We aimed to evaluate the literature comparing low birth weight (LBW) and neurodevelopmental and neurobehavioural outcomes for children whose mothers took antidepressants in pregnancy compared to those whose mothers had common mental disorders, or symptoms, but who did not take antidepressants during pregnancy. A systematic review was conducted searching PubMed, MEDLINE, PsycINFO and Embase in January 2015. A modified version of the Newcastle Ottawa Scale was used to assess study quality. Eleven cohort studies were included: four reporting a LBW outcome (all with higher risk of bias) and seven reporting a neurodevelopmental outcome (five with higher risk of bias). We found only limited evidence of gestational age-adjusted LBW in exposed children in two studies which had a higher risk of bias and did not control for depressive symptom severity. Only five (7.5%) neurodevelopmental outcomes and one (12.5%) neurobehavioural outcome showed evidence of a statistically significant effect, three out of four were from studies with a higher risk of bias. There is little robust evidence indicating a detrimental effect of antidepressant use during pregnancy on LBW and neurodevelopmental and neurobehavioural outcomes. More rigorous study designs are needed.
Language eng
DOI 10.1007/s00737-017-0780-3
Field of Research 110319 Psychiatry (incl Psychotherapy)
111006 Midwifery
1701 Psychology
Socio Economic Objective 920507 Women's Health
HERDC Research category C2.1 Other contribution to refereed journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103315

Document type: Journal Article
Collections: School of Psychology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.