Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide

Ankers, Elizabeth A, Evison, Benny J, Phillips, Don R, Brownlee, Robert TC and Cutts, Suzanne M 2014, Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide, Bioorganic and medicinal chemistry letters, vol. 24, no. 24, pp. 5710-5715, doi: 10.1016/j.bmcl.2014.10.062.

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Title Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide
Author(s) Ankers, Elizabeth AORCID iD for Ankers, Elizabeth A orcid.org/0000-0002-5779-7116
Evison, Benny J
Phillips, Don R
Brownlee, Robert TC
Cutts, Suzanne M
Journal name Bioorganic and medicinal chemistry letters
Volume number 24
Issue number 24
Start page 5710
End page 5715
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-12-15
ISSN 0960-894X
1464-3405
Keyword(s) acridine-4-carboxamide
DNA adducts
energy minimized 3D model
formaldehyde activation
transcription assay
acridines
CpG islands
disinfectants
drug design
formaldehyde
isoquinolines
models, molecular
molecular structure
topoisomerase II inhibitors
science & technology
life sciences & biomedicine
physical sciences
chemistry, medicinal
chemistry, organic
pharmacology & pharmacy
chemistry
Language eng
DOI 10.1016/j.bmcl.2014.10.062
Field of Research 0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
0305 Organic Chemistry
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103327

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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