Investigating metal aberrations in cellular senescence

Masaldan, Shashank 2017, Investigating metal aberrations in cellular senescence, PhD thesis, School of Life and Environmental Sciences, Deakin University.

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Title Investigating metal aberrations in cellular senescence
Author Masaldan, ShashankORCID iD for Masaldan, Shashank orcid.org/0000-0003-4960-4983
Institution Deakin University
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name PhD
Thesis advisor Cater, Michael
Date submitted 2017-06
Keyword(s) ageing
autophagy
healthspan
senescence
ferritin
ferritinophagy
ferroptosis
Summary  This study explored perturbations in iron and copper homeostasis in senescent cells that contribute to age-associated disease and dysfunction. Altered metal regulation was associated with impaired cellular autophagy and resulted in extreme resistance to ferroptosis, a novel iron mediated cell death process linked to various pathologies.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
Description of original xiii, 178 pages, plus appendices: illustrations graphs, some coloured
Restricted until 2018-02-01
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103501

Document type: Thesis
Collection: Higher degree theses (citation only)
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Created: Thu, 19 Oct 2017, 07:13:25 EST by Asif, Yasmin

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