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Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia

Gunaletchumy, Selva Perumal, Seevasant, Indran, Tan, Mun Hua, Croft, Laurence J., Mitchell, Hazel M., Goh, Khean Lee, Loke, Mun Fai and Vadivelu, Jamuna 2014, Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia, Scientific Reports, vol. 4, pp. 1-9, doi: 10.1038/srep07431.

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Title Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia
Author(s) Gunaletchumy, Selva Perumal
Seevasant, Indran
Tan, Mun HuaORCID iD for Tan, Mun Hua orcid.org/0000-0003-3396-8213
Croft, Laurence J.ORCID iD for Croft, Laurence J. orcid.org/0000-0001-8471-2408
Mitchell, Hazel M.
Goh, Khean Lee
Loke, Mun Fai
Vadivelu, Jamuna
Journal name Scientific Reports
Volume number 4
Article ID 7431
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2014-12-11
ISSN 2045-2322
2045-2322
Keyword(s) Amino Acid Sequence
Bacterial Outer Membrane Proteins
Fructose-Bisphosphate Aldolase
Gastritis
Genes, Bacterial
Genetic Association Studies
Genetic Variation
Helicobacter Infections
Helicobacter pylori
Humans
Malaysia
Molecular Sequence Data
Multilocus Sequence Typing
Peptic Ulcer
Phylogeny
Stomach Neoplasms
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CAGA EPIYA MOTIF
GASTRIC-CANCER
VARIABLE REGION
INFECTION
GENOME
INTERLEUKIN-8
STRAINS
CHINA
VACA
ASIA
Summary Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.
Language eng
DOI 10.1038/srep07431
Field of Research 110801 Medical Bacteriology
060503 Microbial Genetics
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103674

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.