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Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection

Zheng, Yuanhui, Soeriyadi, Alexander H., Rosa, Lorenzo, Ng, Soon Hock, Bach, Udo and Gooding, J. Justin 2015, Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection, Nature communications, vol. 6, pp. 1-8, doi: 10.1038/ncomms9797.

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Title Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection
Author(s) Zheng, Yuanhui
Soeriyadi, Alexander H.
Rosa, Lorenzo
Ng, Soon Hock
Bach, Udo
Gooding, J. Justin
Journal name Nature communications
Volume number 6
Article ID 8797
Start page 1
End page 8
Total pages 8
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2015-11-09
ISSN 2041-1723
Summary Single-molecule surface-enhanced Raman spectroscopy (SERS) has attracted increasing interest for chemical and biochemical sensing. Many conventional substrates have a broad distribution of SERS enhancements, which compromise reproducibility and result in slow response times for single-molecule detection. Here we report a smart plasmonic sensor that can reversibly trap a single molecule at hotspots for rapid single-molecule detection. The sensor was fabricated through electrostatic self-assembly of gold nanoparticles onto a gold/silica-coated silicon substrate, producing a high yield of uniformly distributed hotspots on the surface. The hotspots were isolated with a monolayer of a thermoresponsive polymer (poly(N-isopropylacrylamide)), which act as gates for molecular trapping at the hotspots. The sensor shows not only a good SERS reproducibility but also a capability to repetitively trap and release molecules for single-molecular sensing. The single-molecule sensitivity is experimentally verified using SERS spectral blinking and bianalyte methods.
Language eng
DOI 10.1038/ncomms9797
Field of Research MD Multidisciplinary
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Macmillan Publishers
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103807

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.