Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis

Lim, Siew S, Davies, MJ, Norman, RJ and Moran, LJ 2012, Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis, Human reproduction update, vol. 18, no. 6, pp. 618-637, doi: 10.1093/humupd/dms030.

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Title Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis
Author(s) Lim, Siew SORCID iD for Lim, Siew S orcid.org/0000-0002-5333-6451
Davies, MJ
Norman, RJ
Moran, LJ
Journal name Human reproduction update
Volume number 18
Issue number 6
Start page 618
End page 637
Total pages 20
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2012-11-01
ISSN 1355-4786
1460-2369
Keyword(s) adolescent
adult
age factors
female
humans
obesity
overweight
polycystic ovary syndrome
prevalence
meta-analysis
central obesity
Summary BACKGROUND Polycystic ovary syndrome (PCOS) is closely associated with obesity but the prevalence of obesity varies between published studies. The objective of this research was to describe the prevalence of overweight, obesity and central obesity in women with and without PCOS and to assess the confounding effect of ethnicity, geographic regions and the diagnostic criteria of PCOS on the prevalence. METHODS MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and PSYCINFO were searched for studies reporting the prevalence of overweight, obesity or central obesity in women with and without PCOS. Data were presented as prevalence (%) and risk ratio (RR) [95% confidence interval (CI)]. Random-effect models were used to calculate pooled RR. RESULTS This systematic review included 106 studies while the meta-analysis included 35 studies (15129 women). Women with PCOS had increased prevalence of overweight [RR (95% CI): 1.95 (1.52, 2.50)], obesity [2.77 (1.88, 4.10)] and central obesity [1.73 (1.31, 2.30)] compared with women without PCOS. The Caucasian women with PCOS had a greater increase in obesity prevalence than the Asian women with PCOS compared with women without PCOS [10.79 (5.36, 21.70) versus 2.31 (1.33, 4.00), P < 0.001 between subgroups). CONCLUSIONS Women with PCOS had a greater risk of overweight, obesity and central obesity. Although our findings support a positive association between obesity and PCOS, our conclusions are limited by the significant heterogeneity between studies and further studies are now required to determine the source of this heterogeneity. Clinical management of PCOS should include the prevention and management of overweight and obesity.
Language eng
DOI 10.1093/humupd/dms030
Field of Research 111799 Public Health and Health Services not elsewhere classified
1114 Paediatrics And Reproductive Medicine
1117 Public Health And Health Services
1103 Clinical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103901

Document type: Journal Article
Collection: Population Health
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