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Evaluating the impact of depression, anxiety & autonomic function on health related quality of life, vocational functioning and health care utilisation in acute coronary syndrome patients: the ADVENT study protocol

Oldroyd, John C., Cyril, Sheila, Wijayatilaka, Bhanuja S., O'Neil, Adrienne, McKenzie, Dean P., Zavarsek, Silva, Sanderson, Kristy, Hare, David L., Fisher, Aaron J., Forbes, Andrew B., Barr Taylor, C., Clarke, David M., Meredith, Ian T. and Oldenburg, Brian 2013, Evaluating the impact of depression, anxiety & autonomic function on health related quality of life, vocational functioning and health care utilisation in acute coronary syndrome patients: the ADVENT study protocol, BMC cardiovascular disorders, vol. 13, pp. 1-9, doi: 10.1186/1471-2261-13-103.

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Title Evaluating the impact of depression, anxiety & autonomic function on health related quality of life, vocational functioning and health care utilisation in acute coronary syndrome patients: the ADVENT study protocol
Author(s) Oldroyd, John C.
Cyril, Sheila
Wijayatilaka, Bhanuja S.
O'Neil, Adrienne
McKenzie, Dean P.
Zavarsek, SilvaORCID iD for Zavarsek, Silva orcid.org/0000-0002-7898-1406
Sanderson, Kristy
Hare, David L.
Fisher, Aaron J.
Forbes, Andrew B.
Barr Taylor, C.
Clarke, David M.
Meredith, Ian T.
Oldenburg, Brian
Journal name BMC cardiovascular disorders
Volume number 13
Article ID 103
Start page 1
End page 9
Total pages 9
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2013-11-17
ISSN 1471-2261
Keyword(s) Activities of Daily Living
Acute Coronary Syndrome
Anxiety
Cohort Studies
Depression
Female
Follow-Up Studies
Heart Rate
Humans
Male
Patient Acceptance of Health Care
Prospective Studies
Quality of Life
Victoria
Summary BACKGROUND: Depression and anxiety are highly prevalent and co-morbid in acute coronary syndrome patients. Somatic and cognitive subtypes of depression and anxiety in acute coronary syndrome have been shown to be associated with mortality although their association with patient outcomes is unknown, as are the mechanisms that underpin these associations. We are conducting a prospective cohort study which aims to examine in acute coronary syndrome patients: (1) the role of somatic subtypes of depression and anxiety as predictors of health related quality of life outcomes; (2) how somatic subtypes of depression and anxiety relate to long term vocational functioning and healthcare utilisation; and (3) the role of the autonomic nervous system assessed by heart rate variability as a moderator of these associations.

METHODS: Patients are being screened after index admission for acute coronary syndrome at a single, high volume centre, MonashHeart, Monash Health, Victoria, Australia. The inclusion criterion is all patients aged > 21 years old and fluent in English admitted to MonashHeart, Monash Health with a diagnosis of acute coronary syndrome. The primary outcome is mean health related quality of life (Short Form-36) Physical and Mental Health Summary scores at 12 and 24 months in subtypes with somatic symptoms of depression and anxiety. Depressive domains are assessed by the Beck Depression Inventory II and the Cardiac Depression Scale. Anxiety is measured using the Speilberger State-Trait Anxiety Inventory and the Crown Crisp Phobic Anxiety questionnaire. Secondary outcomes include clinical variables, healthcare service utilisation and vocational functioning.

DISCUSSION: This manuscript presents the protocol for a prospective cohort study which will investigate the role of somatic subtypes of depression and anxiety as predictors of health related quality of life, long-term vocational functioning and health service use, and the role of the autonomic nervous system in moderating these associations. Findings from the study have the potential to inform more effective pharmacological, psychological and behavioural interventions and better guide health policy on the use of health care resources.
Language eng
DOI 10.1186/1471-2261-13-103
Field of Research 1102 Cardiovascular Medicine And Haematology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30103944

Document type: Journal Article
Collections: School of Health and Social Development
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.