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Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells

Chen, Chunhai, Ma, Qinlong, Liu, Chuan, Deng, Ping, Zhu, Gang, Zhang, Lei, He, Mindi, Lu, Yonghui, Duan, Weixia, Pei, Liping, Li, Min, Yu, Zhengping and Zhou, Zhou 2014, Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells, Scientific reports, vol. 4, pp. 1-10, doi: 10.1038/srep05103.

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Title Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells
Author(s) Chen, Chunhai
Ma, Qinlong
Liu, Chuan
Deng, Ping
Zhu, Gang
Zhang, Lei
He, Mindi
Lu, Yonghui
Duan, WeixiaORCID iD for Duan, Weixia orcid.org/0000-0001-5782-9184
Pei, Liping
Li, Min
Yu, Zhengping
Zhou, Zhou
Journal name Scientific reports
Volume number 4
Article ID 5103
Start page 1
End page 10
Total pages 10
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2014-05-29
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Summary A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important for exploring the effects of RF-EMF on brain development. Here, we exposed eNSCs to 1800 MHz RF-EMF at specific absorption rate (SAR) values of 1, 2, and 4 W/kg for 1, 2, and 3 days. We found that 1800 MHz RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle or the mRNA expressions of related genes. RF-EMF exposure also did not alter the ratio of eNSC differentiated neurons and astrocytes. However, neurite outgrowth of eNSC differentiated neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. Additionally, the mRNA and protein expression of the proneural genes Ngn1 and NeuroD, which are crucial for neurite outgrowth, were decreased after RF-EMF exposure. The expression of their inhibitor Hes1 was upregulated by RF-EMF exposure. These results together suggested that 1800 MHz RF-EMF exposure impairs neurite outgrowth of eNSCs. More attention should be given to the potential adverse effects of RF-EMF exposure on brain development.
Language eng
DOI 10.1038/srep05103
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30104083

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.