Dissolution-enhancing mechanism of alkalizers in poloxamer-based solid dispersions and physical mixtures containing poorly water-soluble valsartan

Ha, Nam Sung, Tran, Thao Truong-Dinh, Tran, Phuong Ha Lien, Park, Jun-Bom and Lee, Beom-Jin 2011, Dissolution-enhancing mechanism of alkalizers in poloxamer-based solid dispersions and physical mixtures containing poorly water-soluble valsartan, Chemical and pharmaceutical bulletin, vol. 59, no. 7, pp. 844-850, doi: 10.1248/cpb.59.844.

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Title Dissolution-enhancing mechanism of alkalizers in poloxamer-based solid dispersions and physical mixtures containing poorly water-soluble valsartan
Author(s) Ha, Nam Sung
Tran, Thao Truong-Dinh
Tran, Phuong Ha LienORCID iD for Tran, Phuong Ha Lien orcid.org/0000-0001-8463-7516
Park, Jun-Bom
Lee, Beom-Jin
Journal name Chemical and pharmaceutical bulletin
Volume number 59
Issue number 7
Start page 844
End page 850
Total pages 7
Publisher Pharmaceutical Society of Japan
Place of publication Tokyo, Japan
Publication date 2011
ISSN 0009-2363
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Chemistry, Medicinal
Chemistry, Multidisciplinary
Pharmacology & Pharmacy
Chemistry
valsartan
alkalizer
solid dispersion
structural change
drug dissolution
microenvironmental pH
ORAL BIOAVAILABILITY
BETA-CYCLODEXTRIN
SOLUBILITY
DRUG
ENHANCEMENT
RELEASE
SULFATHIAZOLE
INDOMETHACIN
ITRACONAZOLE
Language eng
DOI 10.1248/cpb.59.844
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Pharmaceutical Society of Japan
Persistent URL http://hdl.handle.net/10536/DRO/DU:30104580

Document type: Journal Article
Collection: School of Medicine
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