Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles

Tran, Ha Lien Phuong, Tran, Thao Truong-Dinh and Lee, Beom-Jin 2013, Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles, International journal of pharmaceutics, vol. 455, no. 1-2, pp. 235-240, doi: 10.1016/j.ijpharm.2013.07.025.

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Title Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Tran, Thao Truong-Dinh
Lee, Beom-Jin
Journal name International journal of pharmaceutics
Volume number 455
Issue number 1-2
Start page 235
End page 240
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-10-15
ISSN 1873-3476
Keyword(s) Enhanced solubility
Gelatin–oleic acid conjugate
Modified release
Poorly water-soluble drugs
Self-assembled nanoparticles
pH-dependent solubility
Benzimidazoles
Benzoates
Diclofenac
Gelatin
Nanoparticles
Oleic Acid
Particle Size
Powder Diffraction
Solubility
Spectroscopy, Fourier Transform Infrared
Tetrazoles
Valine
Valsartan
Water
X-Ray Diffraction
Summary Recently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs. Three poorly water-soluble model drugs with different pH-dependent solubility (valsartan and aceclofenac, insoluble at pH 1.2; telmisartan, insoluble at pH 6.8) were chosen to investigate the potential contributions of self-assembled GO nanoparticles to solubility enhancement and controlled release. The particle size of the drug-loaded nanoparticles was 200-250 nm. Zeta potential was calculated, and instrumental analysis such as powder X-ray diffraction (PXRD) and Fourier transform infrared (FT-IR) spectroscopy were used to investigate the physicochemical properties of the drug-loaded nanoparticles. Compared to the drug alone, the drug-loaded nanoparticles showed enhanced solubility. Furthermore, the release profiles of the model drugs were modified in a controlled manner. The current self-assembled GO nanoparticles can provide a versatile potential in drug delivery and tumor targeting.
Language eng
DOI 10.1016/j.ijpharm.2013.07.025
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30104598

Document type: Journal Article
Collection: School of Medicine
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