Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson's disease: a systematic review and meta-analysis Goodwill, Alicia M, Lum, Jarrad AG, Hendy, Ashlee M, Muthalib, Makii, Johnson, Liam, Albein-Urios, Natalia and Teo, Wei-Peng 2017, Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson's disease: a systematic review and meta-analysis, Scientific reports, vol. 7, no. 1, pp. 1-11, doi: 10.1038/s41598-017-13260-z. Attached Files Name Description MIMEType Size Downloads lum-usingnoninvasive-2017.pdf Published version application/pdf 1.99MB 109 Title Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson's disease: a systematic review and meta-analysis Author(s) Goodwill, Alicia M Lum, Jarrad AG orcid.org/0000-0003-2098-2403 Hendy, Ashlee M orcid.org/0000-0002-9043-8385 Muthalib, Makii Johnson, Liam Albein-Urios, Natalia orcid.org/0000-0001-7841-018X Teo, Wei-Peng orcid.org/0000-0003-3929-9778 Journal name Scientific reports Volume number 7 Issue number 1 Article ID 14840 Start page 1 End page 11 Total pages 11 Publisher Nature Publishing Group Place of publication London, Eng. Publication date 2017-11-01 ISSN 2045-2322 2045-2322 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics HIGH-FREQUENCY RTMS MAGNETIC STIMULATION CORTICAL EXCITABILITY BRAIN-STIMULATION INDUCED DYSKINESIAS PREFRONTAL CORTEX INCIDENT DEMENTIA DOUBLE-BLIND AREA PERFORMANCE Summary Parkinson's disease (PD) is a neurodegenerative disorder affecting motor and cognitive abilities. There is no cure for PD, therefore identifying safe therapies to alleviate symptoms remains a priority. This meta-analysis quantified the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (TES) to improve motor and cognitive dysfunction in PD. PubMed, EMBASE, Web of Science, Google Scholar, Scopus, Library of Congress and Cochrane library were searched. 24 rTMS and 9 TES studies (n = 33) with a sham control group were included for analyses. The Physiotherapy Evidence Database and Cochrane Risk of Bias showed high quality (7.5/10) and low bias with included studies respectively. Our results showed an overall positive effect in favour of rTMS (SMD = 0.394, CI [0.106–0.683], p = 0.007) and TES (SMD = 0.611, CI [0.188–1.035], p = 0.005) compared with sham stimulation on motor function, with no significant differences detected between rTMS and TES (Q [1] = 0.69, p = 0.406). Neither rTMS nor TES improved cognition. No effects for stimulation parameters on motor or cognitive function were observed. To enhance the clinical utility of non-invasive brain stimulation (NBS), individual prescription of stimulation parameters based upon symptomology and resting excitability state should be a priority of future research. Language eng DOI 10.1038/s41598-017-13260-z HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2017, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30105110 Document type: Journal Article Collections: Faculty of Health School of Psychology Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 27 Nov 2017, 07:01:25 EST Tue, 28 Nov 2017, 04:00:10 EST Tue, 28 Nov 2017, 07:32:27 EST Thu, 14 Dec 2017, 05:02:50 EST Thu, 14 Dec 2017, 14:04:54 EST Thu, 14 Dec 2017, 14:06:43 EST Thu, 14 Dec 2017, 14:07:18 EST Fri, 15 Dec 2017, 08:34:39 EST Fri, 07 Sep 2018, 17:53:09 EST Filtered Full Citation counts:   Cited 20 times in TR Web of Science Cited 23 times in Scopus Search Google Scholar Access Statistics: 457 Abstract Views, 110 File Downloads  -  Detailed Statistics Created: Mon, 27 Nov 2017, 07:01:25 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.