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Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential

Agrawal, Shivankar, Acharya, Debabrata, Adholeya, Alok, Barrow, Colin J and Deshmukh, Sunil K 2017, Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential, Frontiers in pharmacology, vol. 8, pp. 1-26, doi: 10.3389/fphar.2017.00828.

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Title Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential
Author(s) Agrawal, Shivankar
Acharya, Debabrata
Adholeya, Alok
Barrow, Colin JORCID iD for Barrow, Colin J orcid.org/0000-0002-2153-7267
Deshmukh, Sunil K
Journal name Frontiers in pharmacology
Volume number 8
Article ID 828
Start page 1
End page 26
Total pages 26
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2017-11
ISSN 1663-9812
Keyword(s) anticancer
antimicrobial
marine natural products
microbe derived-compounds
nonribosomal peptides
science & technology
life sciences & biomedicine
pharmacology & pharmacy
Summary Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.
Language eng
DOI 10.3389/fphar.2017.00828
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Agrawal, Acharya, Adholeya, Barrow and Deshmukh
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30105663

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.