Interhemispheric cortical inhibition is reduced in young adults with developmental coordination disorder

He, Jason L, Fuelscher, Ian, Enticott, Peter G, Teo, Wei-Peng, Barhoun, Pamela and Hyde, Christian 2018, Interhemispheric cortical inhibition is reduced in young adults with developmental coordination disorder, Frontiers in neurology, vol. 9, pp. 1-12, doi: 10.3389/fneur.2018.00179.

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Title Interhemispheric cortical inhibition is reduced in young adults with developmental coordination disorder
Author(s) He, Jason L
Fuelscher, IanORCID iD for Fuelscher, Ian
Enticott, Peter GORCID iD for Enticott, Peter G
Teo, Wei-PengORCID iD for Teo, Wei-Peng
Barhoun, Pamela
Hyde, ChristianORCID iD for Hyde, Christian
Journal name Frontiers in neurology
Volume number 9
Article ID 179
Start page 1
End page 12
Total pages 12
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2018-03-23
ISSN 1664-2295
Keyword(s) cortical inhibition
developmental coordination disorder
interhemispheric connectivity
motor control
movement disorders
transcranial magnetic stimulation
science & technology
life sciences & biomedicine
clinical neurology
neurosciences & neurology
Summary Introduction: While the etiology of developmental coordination disorder (DCD) is yet to be established, brain-behavior modeling provides a cogent argument that neuropathology may subserve the motor difficulties typical of DCD. We argue that a number of the core behavioral features of the DCD profile (such as poor surround inhibition, compromised motor inhibition, and the presence of mirror movements) are consistent with difficulties regulating inhibition within the primary motor cortex (M1). This study aimed to be the first account of the integrity of cortical inhibition in motor cortices in DCD. Method: The sample consisted of eight adults with DCD aged (18-30 years) and 10 aged matched neurotypical controls. Participants received a common battery of single and paired-pulse transcranial magnetic stimulation from which a series of neurophysiological measures classically used to measure intra- [e.g., short-interval cortical inhibition (SICI), long-interval cortical inhibition (LICI), and cortical silent period] and inter hemispheric [e.g., ipsilateral silent period (ISP)] cortical inhibition of the M1 at rest were recorded. Results: While no group differences were observed for any measure of intrahemispheric cortical inhibition, individuals with DCD demonstrated significantly reduced interhemispheric cortical inhibition relative to controls, shown by consistently lower ISPratios. Conclusion: Our findings are consistent with the view that regulation of cortical inhibition of M1 activity may be atypical in individuals with DCD, indicating differential GABAergic operation. This effect, however, appears to be select to cortical inhibition. Importantly, our data support the notion that reduced interhemispheric M1 cortical inhibition may at least partly explain commonly reported difficulties with bimanual motor control in DCD. The neurochemical implications and limitations of this evidence will be discussed.
Language eng
DOI 10.3389/fneur.2018.00179
Field of Research 1109 Neurosciences
1103 Clinical Sciences
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, He, Fuelscher, Enticott, Teo, Barhoun and Hyde
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Document type: Journal Article
Collection: School of Psychology
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