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Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti

Gaburro, Julie, Bhatti, Asim, Harper, Jenni, Jeanne, Isabelle, Dearnley, Megan, Green, Diane, Nahavandi, Saeid, Paradkar, Prasad N. and Duchemin, Jean-Bernard 2018, Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti, Emerging microbes and infections, vol. 7, no. 1, doi: 10.1038/s41426-018-0069-2.

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Title Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti
Formatted title Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti
Author(s) Gaburro, JulieORCID iD for Gaburro, Julie orcid.org/0000-0001-6609-6429
Bhatti, AsimORCID iD for Bhatti, Asim orcid.org/0000-0001-6876-1437
Harper, Jenni
Jeanne, IsabelleORCID iD for Jeanne, Isabelle orcid.org/0000-0002-5065-9685
Dearnley, Megan
Green, Diane
Nahavandi, SaeidORCID iD for Nahavandi, Saeid orcid.org/0000-0002-0360-5270
Paradkar, Prasad N.
Duchemin, Jean-Bernard
Journal name Emerging microbes and infections
Volume number 7
Issue number 1
Article ID 68
Total pages 11
Publisher Nature Publishing Group
Place of publication United States
Publication date 2018-04-25
ISSN 2222-1751
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Immunology
Microbiology
GUILLAIN-BARRE-SYNDROME
NILE-VIRUS-INFECTION
NERVOUS-SYSTEM
CASE SERIES
DROSOPHILA
GABA
TRANSMISSION
MANIFESTATIONS
VERTEBRATES
COMPETENCE
Summary Understanding Zika virus infection dynamics is essential, as its recent emergence revealed possible devastating neuropathologies in humans, thus causing a major threat to public health worldwide. Recent research allowed breakthrough in our understanding of the virus and host pathogenesis; however, little is known on its impact on its main vector, Aedes aegypti. Here we show how Zika virus targets Aedes aegypti’s neurons and induces changes in its behavior. Results are compared to dengue virus, another flavivirus, which triggers a different pattern of behavioral changes. We used microelectrode array technology to record electrical spiking activity of mosquito primary neurons post infections and discovered that only Zika virus causes an increase in spiking activity of the neuronal network. Confocal microscopy also revealed an increase in synapse connections for Zika virus-infected neuronal networks. Interestingly, the results also showed that mosquito responds to infection by overexpressing glutamate regulatory genes while maintaining virus levels. This neuro-excitation, possibly via glutamate, could contribute to the observed behavioral changes in Zika virus-infected Aedes aegypti females. This study reveals the importance of virus-vector interaction in arbovirus neurotropism, in humans and vector. However, it appears that the consequences differ in the two hosts, with neuropathology in human host, while behavioral changes in the mosquito vector that may be advantageous to the virus.
Language eng
DOI 10.1038/s41426-018-0069-2
Field of Research 170205 Neurocognitive Patterns and Neural Networks
110902 Cellular Nervous System
100402 Medical Biotechnology Diagnostics (incl Biosensors)
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30107970

Document type: Journal Article
Collections: Centre for Intelligent Systems Research
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.