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Turning natural adaptations to oncogenic factors into an ally in the war against cancer

Vittecoq, Marion, Giraudeau, Mathieu, Sepp, Tuul, Marcogliese, David J., Klaassen, Marcel, Renaud, Francois, Ujvari, Beata and Thomas, Frederic 2018, Turning natural adaptations to oncogenic factors into an ally in the war against cancer, Evolutionary applications, vol. 11, no. 6, pp. 836-844, doi: 10.1111/eva.12608.

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Title Turning natural adaptations to oncogenic factors into an ally in the war against cancer
Author(s) Vittecoq, Marion
Giraudeau, Mathieu
Sepp, Tuul
Marcogliese, David J.
Klaassen, MarcelORCID iD for Klaassen, Marcel orcid.org/0000-0003-3907-9599
Renaud, Francois
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Thomas, Frederic
Journal name Evolutionary applications
Volume number 11
Issue number 6
Start page 836
End page 844
Total pages 9
Publisher John Wiley & Sons
Place of publication Chichester, Eng.
Publication date 2018-07
ISSN 1752-4563
1752-4571
Keyword(s) cancer resistance
ecotoxicolgy
experimental evolution
pollution
wildlife
ecotoxicology
Science & Technology
Life Sciences & Biomedicine
Evolutionary Biology
KILLIFISH FUNDULUS-HETEROCLITUS
ARYL-HYDROCARBON RECEPTOR
PERCH PERCA-FLAVESCENS
NAKED MOLE-RAT
GENETIC DIVERSITY
UV-RADIATION
ENVIRONMENTAL RADIATION
EVOLUTIONARY TOXICOLOGY
POPULATION-STRUCTURE
CHIRONOMUS-RIPARIUS
Summary Both field and experimental evolution studies have demonstrated that organisms naturally or artificially exposed to environmental oncogenic factors can, sometimes rapidly, evolve specific adaptations to cope with pollutants and their adverse effects on fitness. Although numerous pollutants are mutagenic and carcinogenic, little attention has been given to exploring the extent to which adaptations displayed by organisms living in oncogenic environments could inspire novel cancer treatments, through mimicking the processes allowing these organisms to prevent or limit malignant progression. Building on a substantial knowledge base from the literature, we here present and discuss this progressive and promising research direction, advocating closer collaboration between the fields of medicine, ecology, and evolution in the war against cancer.
Language eng
DOI 10.1111/eva.12608
Field of Research 0603 Evolutionary Biology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30107981

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.