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Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals

Kabeya, Naoki, Fonseca, Miguel M., Ferrier, David E. K., Navarro, Juan C., Bay, Line K., Francis, David S., Tocher, Douglas R., Castro, L. Filipe C. and Monroig, Óscar 2018, Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals, Science advances, vol. 4, no. 5, pp. 1-8, doi: 10.1126/sciadv.aar6849.

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Title Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals
Author(s) Kabeya, Naoki
Fonseca, Miguel M.
Ferrier, David E. K.
Navarro, Juan C.
Bay, Line K.
Francis, David S.ORCID iD for Francis, David S. orcid.org/0000-0002-4829-6926
Tocher, Douglas R.
Castro, L. Filipe C.
Monroig, Óscar
Journal name Science advances
Volume number 4
Issue number 5
Article ID eaar6849
Start page 1
End page 8
Total pages 8
Publisher American Association for the Advancement of Science
Place of publication Washington, D.C.
Publication date 2018-05-02
ISSN 2375-2548
Summary Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or “ωx”) desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes.
Language eng
DOI 10.1126/sciadv.aar6849
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108287

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.