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Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes

Kumar, Janani, Fang, Hao, McCulloch, Daniel R, Crowley, Tamsyn and Ward, Alister 2017, Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes, Oncotarget, vol. 8, no. 55, pp. 93530-93540, doi: 10.18632/oncotarget.19873.

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Title Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes
Author(s) Kumar, Janani
Fang, Hao
McCulloch, Daniel R
Crowley, TamsynORCID iD for Crowley, Tamsyn orcid.org/0000-0002-3698-8917
Ward, AlisterORCID iD for Ward, Alister orcid.org/0000-0001-7945-7975
Journal name Oncotarget
Volume number 8
Issue number 55
Start page 93530
End page 93540
Total pages 11
Publisher Impact Journals
Place of publication Albany, N.Y.
Publication date 2017-08-03
ISSN 1949-2553
Keyword(s) JAK2
STAT3
cancer phenotypes
leptin receptor
ovarian cancer
science & technology
life sciences & biomedicine
oncology
cell biology
Summary Ovarian cancer is a leading cause of cancer mortality in women world-wide. Considerable progress has been made to characterize the different subtypes of ovarian cancer, but specific therapies remain limited and prognosis poor. Cytokine signaling via the interleukin-6 receptor (IL-6R) family and related receptors has been implicated in a number of cancers, including those with an ovarian origin. The leptin receptor (LEPR) is structurally related to these receptors and utilizes similar downstream pathways. LEPR has diverse roles in metabolism, appetite and bone formation with obesity linked to both elevated levels of leptin and increased cancer incidence. This study investigated a potential role for LEPR signaling in ovarian cancer. Leptin stimulation led to increased proliferation, survival and migration of LEPR-expressing ovarian cancer cell lines, with the effects shown to be mediated by the downstream Janus kinase 2/Signal transducer and activator of transcription 3 (JAK2/STAT3) pathway. A significant correlation was identified between high co-expression of leptin and LEPR and decreased patient survival. This study collectively suggests that leptin/LEPR signaling via JAK2/STAT3 has the potential to significantly impact on pathogenesis in a subset of ovarian cancer patients who may benefit from strategies that dampen this pathway.
Language eng
DOI 10.18632/oncotarget.19873
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Kumar et al
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108690

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.