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A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Pedrini, Steve, Gupta, Veer B, Hone, Eugene, Doecke, James, O'Bryant, Sid, James, Ian, Bush, Ashley I, Rowe, Christopher C, Villemagne, Victor L, Ames, David, Masters, Colin L, Martins, Ralph N, Savage, G, Wilson, B, Bourgeat, P, Fripp, J, Gibson, S, Leroux, H, McBride, S, Salvado, O, Fenech, M, Francois, M, Barnes, M, Baker, J, Barnham, K, Bellingham, S, Bomke, J, Pejoska, SB, Buckley, R, Cheng, L, Collins, S, Cooke, I, Cyarto, E, Darby, D, Dore, V, El-Sheikh, D, Faux, N, Fowler, C, Harrington, K, Hill, A, Horne, M, Jones, G, Kamer, A, Killeen, N, Korrel, H, Lamb, F, Lautenschlager, N, Lennon, K, Li, QX, Lim, YY, Louey, A, Macaulay, L, Mackintosh, L, Maruff, P, McIlroy, A, Nigro, J, Perez, K, Pertile, K, Restrepo, C, Rita Cardoso, Barbara, Rembach, A, Roberts, B, Robertson, J, Rumble, R, Ryan, T, Sach, J, Silbert, B, Thai, C, Trounson, B, Volitakis, I, Vovos, M, Ward, L, Watt, A, Williams, R, Woodward, M, Yates, P, Ugarte, FY, Zhang, P, Bird, S, Brown, B, Burnham, S, Chatterjee, P, Cox, K, Fernandez, S, Fernando, B, Gardener, S, Laws, S, Lim, F, Lim, L, Tegg, M, Lucas, K and Martins, G 2017, A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort, Scientific reports, vol. 7, pp. 1-12, doi: 10.1038/s41598-017-14020-9.

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Title A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
Author(s) Pedrini, Steve
Gupta, Veer B
Hone, Eugene
Doecke, James
O'Bryant, Sid
James, Ian
Bush, Ashley I
Rowe, Christopher C
Villemagne, Victor L
Ames, David
Masters, Colin L
Martins, Ralph N
Savage, G
Wilson, B
Bourgeat, P
Fripp, J
Gibson, S
Leroux, H
McBride, S
Salvado, O
Fenech, M
Francois, M
Barnes, M
Baker, J
Barnham, K
Bellingham, S
Bomke, J
Pejoska, SB
Buckley, R
Cheng, L
Collins, S
Cooke, I
Cyarto, E
Darby, D
Dore, V
El-Sheikh, D
Faux, N
Fowler, C
Harrington, K
Hill, A
Horne, M
Jones, G
Kamer, A
Killeen, N
Korrel, H
Lamb, F
Lautenschlager, N
Lennon, K
Li, QX
Lim, YY
Louey, A
Macaulay, L
Mackintosh, L
Maruff, P
McIlroy, A
Nigro, J
Perez, K
Pertile, K
Restrepo, C
Rita Cardoso, BarbaraORCID iD for Rita Cardoso, Barbara orcid.org/0000-0002-6393-1377
Rembach, A
Roberts, B
Robertson, J
Rumble, R
Ryan, T
Sach, J
Silbert, B
Thai, C
Trounson, B
Volitakis, I
Vovos, M
Ward, L
Watt, A
Williams, R
Woodward, M
Yates, P
Ugarte, FY
Zhang, P
Bird, S
Brown, B
Burnham, S
Chatterjee, P
Cox, K
Fernandez, S
Fernando, B
Gardener, S
Laws, S
Lim, F
Lim, L
Tegg, M
Lucas, K
Martins, G
Journal name Scientific reports
Volume number 7
Article ID 14057
Start page 1
End page 12
Total pages 12
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2017-12-01
ISSN 2045-2322
Keyword(s) Alzheimer’s Disease (AD)
dementia
extracellular amyloid deposition
tau protein
risk
Summary Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ϵ4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ϵ4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.
Language eng
DOI 10.1038/s41598-017-14020-9
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108765

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.