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The effect of polyphenol-rich interventions on cardiovascular risk factors in haemodialysis: a systematic review and meta-analysis

Marx, Wolfgang, Kelly, Jaimon, Marshall, Skye, Nakos, Stacey, Campbell, Katrina and Itsiopoulos, Catherine 2017, The effect of polyphenol-rich interventions on cardiovascular risk factors in haemodialysis: a systematic review and meta-analysis, Nutrients, vol. 9, no. 12, doi: 10.3390/nu9121345.

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Title The effect of polyphenol-rich interventions on cardiovascular risk factors in haemodialysis: a systematic review and meta-analysis
Author(s) Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
Kelly, Jaimon
Marshall, Skye
Nakos, Stacey
Campbell, Katrina
Itsiopoulos, Catherine
Journal name Nutrients
Volume number 9
Issue number 12
Article ID 1345
Total pages 24
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2017-12-11
ISSN 2072-6643
Keyword(s) blood pressure
cardiovascular
cocoa
dialysis
inflammation
meta-analysis
oxidative stress
polyphenol
pomegranate
review
soy
turmeric
Summary End-stage kidney disease is a strong risk factor for cardiovascular-specific mortality. Polyphenol-rich interventions may attenuate cardiovascular disease risk factors; however, this has not been systematically evaluated in the hemodialysis population. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases were searched: Cochrane Library (http://www.cochranelibrary.com/), MEDLINE (https://health.ebsco.com/products/medline-with-full-text), Embase (https://www.elsevier.com/solutions/embase-biomedical-research), and CINAHL (https://www.ebscohost.com/nursing/products/cinahl-databases/cinahl-complete). Meta-analyses were conducted for measures of lipid profile, inflammation, oxidative stress, and blood pressure. Risk of bias was assessed using the Cochrane Collaboration Risk of Bias tool and quality of the body of evidence was assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. Twelve studies were included for review. Polyphenol-rich interventions included soy, cocoa, pomegranate, grape, and turmeric. Polyphenol-rich interventions significantly improved diastolic blood pressure (Mean Difference (MD) -5.62 mmHg (95% Confidence Interval (CI) -8.47, -2.78); I² = 2%; p = 0.0001), triglyceride levels (MD -26.52 mg/dL (95% CI -47.22, -5.83); I² = 57%; p = 0.01), and myeloperoxidase (MD -90.10 (95% CI -135.84, -44.36); I² = 0%; p = 0.0001). Included studies generally had low or unclear risks of bias. The results of this review provide preliminary support for the use of polyphenol-rich interventions for improving cardiovascular risk markers in haemodialysis patients. Due to the limited number of studies for individual polyphenol interventions, further studies are required to provide recommendations regarding individual polyphenol intervention and dose.
Language eng
DOI 10.3390/nu9121345
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108805

Document type: Journal Article
Collections: School of Medicine
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