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The effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: a double blind, randomized, placebo controlled trial

Marx, Wolfgang, McCarthy, Alexandra L., Ried, Karin, McKavanagh, Dan, Vitetta, Luis, Sali, Avni, Lohning, Anna and Isenring, Elisabeth 2017, The effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: a double blind, randomized, placebo controlled trial, Nutrients, vol. 9, no. 8, doi: 10.3390/nu9080867.

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Title The effect of a standardized ginger extract on chemotherapy-induced nausea-related quality of life in patients undergoing moderately or highly emetogenic chemotherapy: a double blind, randomized, placebo controlled trial
Author(s) Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
McCarthy, Alexandra L.
Ried, Karin
McKavanagh, Dan
Vitetta, Luis
Sali, Avni
Lohning, Anna
Isenring, Elisabeth
Journal name Nutrients
Volume number 9
Issue number 8
Total pages 13
Publisher M D P I AG
Place of publication Basel, Switzerland
Publication date 2017-08-12
ISSN 2072-6643
Keyword(s) CINV
cancer
dietary supplements
emesis
ginger
nausea
Adult
Aged
Antineoplastic Agents
Double-Blind Method
Humans
Middle Aged
Plant Extracts
Quality of Life
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
PATIENTS RECEIVING CISPLATIN
CANCER-RELATED FATIGUE
FUNCTIONAL ASSESSMENT
CONSENSUS CONFERENCE
RADIOTHERAPY
PREVENTION
THERAPY
IMPACT
PHARMACOKINETICS
Summary Ginger supplementation could be an effective adjuvant treatment for chemotherapy-induced nausea (CIN). The aim of this clinical trial was to address significant methodological limitations in previous trials. Patients (N = 51) were randomly allocated to receive either 1.2 g of standardised ginger extract or placebo per day, in addition to standard anti-emetic therapy, during the first three cycles of chemotherapy. The primary outcome was CIN-related quality of life (QoL) measured with the Functional Living Index- Emesis (FLIE) questionnaire. Secondary outcomes included acute and delayed nausea, vomiting, and retching as well as cancer-related fatigue, nutritional status, and CIN and vomiting-specific prognostic factors. Over three consecutive chemotherapy cycles, nausea was more prevalent than vomiting (47% vs. 12%). In chemotherapy Cycle 1, intervention participants reported significantly better QoL related to CIN (p = 0.029), chemotherapy-induced nausea and vomiting (CINV)-related QoL (p = 0.043), global QoL (p = 0.015) and less fatigue (p = 0.006) than placebo participants. There were no significant results in Cycle 2. In Cycle 3, global QoL (p = 0.040) and fatigue (p = 0.013) were significantly better in the intervention group compared to placebo. This trial suggests adjuvant ginger supplementation is associated with better chemotherapy-induced nausea-related quality of life and less cancer-related fatigue, with no difference in adverse effects compared to placebo.
Language eng
DOI 10.3390/nu9080867
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108809

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.