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An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction

Adams, Scott D., Kouzani, Abbas, Tye, Susannah J., Bennet, Kevin E. and Berk, Michael 2018, An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction, Journal of neuroengineering and rehabilitation, vol. 15, pp. 1-18, doi: 10.1186/s12984-018-0349-z.

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Title An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction
Author(s) Adams, Scott D.
Kouzani, AbbasORCID iD for Kouzani, Abbas orcid.org/0000-0002-6292-1214
Tye, Susannah J.
Bennet, Kevin E.
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Journal of neuroengineering and rehabilitation
Volume number 15
Article ID 8
Start page 1
End page 18
Total pages 18
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2018-02-13
ISSN 1743-0003
1743-0003
Keyword(s) ATP sensing
Closed-loop
Deep brain stimulation
Mitochondrial function
Oxidative stress
Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Neurosciences
Rehabilitation
Engineering
Neurosciences & Neurology
DEEP-BRAIN-STIMULATION
AMYOTROPHIC-LATERAL-SCLEROSIS
SCAN CYCLIC VOLTAMMETRY
MAJOR DEPRESSIVE DISORDER
TREATMENT-RESISTANT DEPRESSION
DRUG-DELIVERY SYSTEM
COMPLEX I DEFICIENCY
FREELY-MOVING RATS
URIC-ACID LEVELS
PARKINSONS-DISEASE
Summary Dynamic feedback based closed-loop medical devices offer a number of advantages for treatment of heterogeneous neurological conditions. Closed-loop devices integrate a level of neurobiological feedback, which allows for real-time adjustments to be made with the overarching aim of improving treatment efficacy and minimizing risks for adverse events. One target which has not been extensively explored as a potential feedback component in closed-loop therapies is mitochondrial function. Several neurodegenerative and psychiatric disorders including Parkinson’s disease, Major Depressive disorder and Bipolar disorder have been linked to perturbations in the mitochondrial respiratory chain. This paper investigates the potential to monitor this mitochondrial function as a method of feedback for closed-loop neuromodulation treatments. A generic model of the closed-loop treatment is developed to describe the high-level functions of any system designed to control neural function based on mitochondrial response to stimulation, simplifying comparison and future meta-analysis. This model has four key functional components including: a sensor, signal manipulator, controller and effector. Each of these components are described and several potential technologies for each are investigated. While some of these candidate technologies are quite mature, there are still technological gaps remaining. The field of closed-loop medical devices is rapidly evolving, and whilst there is a lot of interest in this area, widespread adoption has not yet been achieved due to several remaining technological hurdles. However, the significant therapeutic benefits offered by this technology mean that this will be an active area for research for years to come.
Language eng
DOI 10.1186/s12984-018-0349-z
Field of Research 0903 Biomedical Engineering
1109 Neurosciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108838

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.