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Mitochondrial agents for bipolar disorder

Pereira, Ciria, Chavarria, Victor, Vian, Joao, Ashton, Melanie Maree, Berk, Michael, Marx, Wolfgang and Dean, Olivia May 2018, Mitochondrial agents for bipolar disorder, International journal of neuropsychopharmacology, vol. 21, no. 6, pp. 550-569, doi: 10.1093/ijnp/pyy018.

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Title Mitochondrial agents for bipolar disorder
Author(s) Pereira, Ciria
Chavarria, Victor
Vian, Joao
Ashton, Melanie MareeORCID iD for Ashton, Melanie Maree orcid.org/0000-0001-6832-4157
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
Dean, Olivia MayORCID iD for Dean, Olivia May orcid.org/0000-0002-2776-3935
Journal name International journal of neuropsychopharmacology
Volume number 21
Issue number 6
Start page 550
End page 569
Total pages 20
Publisher Oxford Academic
Place of publication London, Eng.
Publication date 2018-06
ISSN 1469-5111
Keyword(s) adjunctive
bipolar disorder
complimentary therapies
mitochondria
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Pharmacology & Pharmacy
Psychiatry
Neurosciences & Neurology
ALPHA-LIPOIC ACID
ACETYL-L-CARNITINE
PLACEBO-CONTROLLED TRIAL
MAGNETIC-RESONANCE-SPECTROSCOPY
MAJOR DEPRESSIVE DISORDER
RANDOMIZED-CLINICAL-TRIAL
VITAMIN-D-RECEPTOR
COMPLEX-I DEFICIENCY
OBESE ZUCKER RATS
DOUBLE-BLIND
Summary Background
Bipolar disorder is a chronic and often debilitating illness. Current treatment options (both pharmaco- and psychotherapy) have shown efficacy, but for many leave a shortfall in recovery. Advances in the understanding of the pathophysiology of bipolar disorder suggest that interventions that target mitochondrial dysfunction may provide a therapeutic benefit.

Methods
This review explores the current and growing theoretical rationale as well as existing preclinical and clinical data for those therapies aiming to target the mitochondrion in bipolar disorder. A Clinicaltrials.gov and ANZCTR search was conducted for complete and ongoing trials on mitochondrial agents used in psychiatric disorders. A PubMed search was also conducted for literature published between January 1981 and July 2017. Systematic reviews, randomized controlled trials, observational studies, case series, and animal studies with an emphasis on agents affecting mitochondrial function and its role in bipolar disorder were included. The search was augmented by manually searching the references of key papers and related literature. The results were presented as a narrative review.

Results
Mitochondrial agents offer new horizons in mood disorder treatment. While some negative effects have been reported, most compounds are overall well tolerated and have generally benign side-effect profiles.

Conclusions
The study of neuroinflammation, neurodegeneration, and mitochondrial function has contributed the understanding of bipolar disorder’s pathophysiology. Agents targeting these pathways could be a potential therapeutic strategy. Future directions include identification of novel candidate mitochondrial modulators as well as rigorous and well-powered clinical trials.
Language eng
DOI 10.1093/ijnp/pyy018
Field of Research 110999 Neurosciences not elsewhere classified
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108880

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.