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Multiple immune-inflammatory and oxidative and nitrosative stress pathways explain the frequent presence of depression in Multiple Sclerosis

Morris, Gerwyn, Reiche, Edna Maria Vissoci, Murru, Andrea, Carvalho, André F., Maes, Michael, Berk, Michael and Puri, Basant K. 2018, Multiple immune-inflammatory and oxidative and nitrosative stress pathways explain the frequent presence of depression in Multiple Sclerosis, Molecular neurobiology, vol. 55, no. 8, pp. 6282-6306, doi: 10.1007/s12035-017-0843-5.

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Title Multiple immune-inflammatory and oxidative and nitrosative stress pathways explain the frequent presence of depression in Multiple Sclerosis
Author(s) Morris, Gerwyn
Reiche, Edna Maria Vissoci
Murru, Andrea
Carvalho, André F.
Maes, Michael
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Puri, Basant K.
Journal name Molecular neurobiology
Volume number 55
Issue number 8
Start page 6282
End page 6306
Total pages 25
Publisher Springer
Place of publication New York, N.Y.
Publication date 2018-08
ISSN 0893-7648
1559-1182
Keyword(s) Depression
Desipramine
Immune function
Inflammation
Lofepramine
Multiple sclerosis
Oxidative and nitrosative stress
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
PITUITARY-ADRENAL AXIS
TREATMENT-RESISTANT DEPRESSION
GERIATRIC BIPOLAR DEPRESSION
NERVOUS-SYSTEM AUTOIMMUNITY
CORTISOL AWAKENING RESPONSE
ARCUATE FASCICULUS REGION
PLACEBO-CONTROLLED TRIAL
DISABILITY STATUS SCALE
REGULATORY T-CELLS
URIC-ACID LEVELS
Summary Patients with a diagnosis of multiple sclerosis (MS) or major depressive disorder (MDD) share a wide array of biological abnormalities which are increasingly considered to play a contributory role in the pathogenesis and pathophysiology of both illnesses. Shared abnormalities include peripheral inflammation, neuroinflammation, chronic oxidative and nitrosative stress, mitochondrial dysfunction, gut dysbiosis, increased intestinal barrier permeability with bacterial translocation into the systemic circulation, neuroendocrine abnormalities and microglial pathology. Patients with MS and MDD also display a wide range of neuroimaging abnormalities and patients with MS who display symptoms of depression present with different neuroimaging profiles compared with MS patients who are depression-free. The precise details of such pathology are markedly different however. The recruitment of activated encephalitogenic Th17 T cells and subsequent bidirectional interaction leading to classically activated microglia is now considered to lie at the core of MS-specific pathology. The presence of activated microglia is common to both illnesses although the pattern of such action throughout the brain appears to be different. Upregulation of miRNAs also appears to be involved in microglial neurotoxicity and indeed T cell pathology in MS but does not appear to play a major role in MDD. It is suggested that the antidepressant lofepramine, and in particular its active metabolite desipramine, may be beneficial not only for depressive symptomatology but also for the neurological symptoms of MS. One clinical trial has been carried out thus far with, in particular, promising MRI findings.
Language eng
DOI 10.1007/s12035-017-0843-5
Field of Research 1109 Neurosciences
1702 Cognitive Science
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30108888

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.