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A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise

Ibáñez, Carlos A, Erthal, Rafaela P, Ogo, Fernanda M, Peres, Maria NC, Vieira, Henrique R, Conejo, Camila, Tófolo, Laize P, Francisco, Flávio A, Silveira, Sandra da Silva, Malta, Ananda, Pavanello, Audrei, Martins, Isabela P, da Silva, Paulo HO, Saavedra, Lucas Paulo Jacinto, Gonçalves, Gessica D, Moreira, Veridiana M, Alves, Vander S, Franco, Claudineia C da Silva, Previate, Carina, Gomes, Rodrigo M, Venci, Renan de Oliveira, Dias, Francielle RS, Armitage, James A, Zambrano, Elena, Mathias, Paulo CF, Fernandes, Glaura SA and Palma-Rigo, Kesia 2017, A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise, Frontiers in physiology, vol. 8, pp. 1-12, doi: 10.3389/fphys.2017.00807.

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Title A high fat diet during adolescence in male rats negatively programs reproductive and metabolic function which is partially ameliorated by exercise
Author(s) Ibáñez, Carlos A
Erthal, Rafaela P
Ogo, Fernanda M
Peres, Maria NC
Vieira, Henrique R
Conejo, Camila
Tófolo, Laize P
Francisco, Flávio A
Silveira, Sandra da Silva
Malta, Ananda
Pavanello, Audrei
Martins, Isabela P
da Silva, Paulo HO
Saavedra, Lucas Paulo Jacinto
Gonçalves, Gessica D
Moreira, Veridiana M
Alves, Vander S
Franco, Claudineia C da Silva
Previate, Carina
Gomes, Rodrigo M
Venci, Renan de Oliveira
Dias, Francielle RS
Armitage, James AORCID iD for Armitage, James A orcid.org/0000-0002-3762-0911
Zambrano, Elena
Mathias, Paulo CF
Fernandes, Glaura SA
Palma-Rigo, Kesia
Journal name Frontiers in physiology
Volume number 8
Article ID 807
Start page 1
End page 12
Total pages 12
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2017-11
ISSN 1664-042X
Keyword(s) high fat diet
moderate exercise
glucose metabolism
obesity
reproductive system
Summary An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study examined metabolic and reproductive function in obese rats programmed by exposure to a high fat (HF) diet during adolescence. The effect of physical training (Ex) in ameliorating this phenotype was also assessed. Thirty-day-old male Wistar rats were fed a HF diet (35% lard w/w) for 30 days then subsequently fed a normal fat diet (NF) for a 40-day recovery period. Control animals were fed a NF diet throughout life. At 70 days of life, animals started a low frequency moderate exercise training that lasted 30 days. Control animals remained sedentary (Se). At 100 days of life, biometric, metabolic and reproductive parameters were evaluated. Animals exposed to HF diet showed greater body weight, glucose intolerance, increased fat tissue deposition, reduced VO 2max and reduced energy expenditure. Consumption of the HF diet led to an increase in the number of abnormal seminiferous tubule and a reduction in seminiferous epithelium height and seminiferous tubular diameter, which was reversed by moderate exercise. Compared with the NF-Se group, a high fat diet decreased the number of seminiferous tubules in stages VII-VIII and the NF-Ex group showed an increase in stages XI-XIII. HF-Se and NF-Ex animals showed a decreased number of spermatozoa in the cauda epididymis compared with animals from the NF-Se group. Animals exposed to both treatments (HF and Ex) were similar to all the other groups, thus these alterations induced by HF or Ex alone were partially prevented. Physical training reduced fat pad deposition and restored altered reproductive parameters. HF diet consumption during the peri-pubertal period induces long-term changes on metabolism and the reproductive system, but moderate and low frequency physical training is able to recover adipose tissue deposition and reproductive system alterations induced by high fat diet. This study highlights the importance of a balanced diet and continued physical activity during adolescence, with regard to metabolic and reproductive health.
Language eng
DOI 10.3389/fphys.2017.00807
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Ibáñez, Erthal, Ogo, Peres, Vieira, Conejo, Tófolo, Francisco, da Silva Silveira, Malta, Pavanello, Martins, da Silva, Jacinto Saavedra, Gonçalves, Moreira, Alves, da Silva Franco, Previate, Gomes, de Oliveira Venci, Dias, Armitage, Zambrano, Mathias, Fernandes and Palma-Rigo
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109082

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.