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Mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study

San-Cristobal, Rodrigo, Navas-Carretero, Santiago, Livingstone, Katherine M, Celis-Morales, Carlos, Macready, Anna L., Fallaize, Rosalind, O'Donovan, Clare B., Lambrinou, Christina P., Moschonis, George, Marsaux, Cyril F.M., Manios, Yannis, Jarosz, Miroslaw, Daniel, Hannelore, Gibney, Eileen R., Brennan, Lorraine, Drevon, Christian A., Gundersen, Thomas E., Gibney, Mike, Saris, Wim H.M., Lovegrove, Julie A., Grimaldi, Keith, Parnell, Laurence D., Bouwman, Jildau, Van Ommen, Ben, Mathers, John C. and Martinez, J. Alfredo 2017, Mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study, Nutrients, vol. 9, no. 10, pp. 1-17, doi: 10.3390/nu9101107.

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Title Mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study
Author(s) San-Cristobal, Rodrigo
Navas-Carretero, Santiago
Livingstone, Katherine MORCID iD for Livingstone, Katherine M orcid.org/0000-0002-9682-7541
Celis-Morales, Carlos
Macready, Anna L.
Fallaize, Rosalind
O'Donovan, Clare B.
Lambrinou, Christina P.
Moschonis, George
Marsaux, Cyril F.M.
Manios, Yannis
Jarosz, Miroslaw
Daniel, Hannelore
Gibney, Eileen R.
Brennan, Lorraine
Drevon, Christian A.
Gundersen, Thomas E.
Gibney, Mike
Saris, Wim H.M.
Lovegrove, Julie A.
Grimaldi, Keith
Parnell, Laurence D.
Bouwman, Jildau
Van Ommen, Ben
Mathers, John C.
Martinez, J. Alfredo
Journal name Nutrients
Volume number 9
Issue number 10
Start page 1
End page 17
Total pages 17
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2017-10-11
ISSN 2072-6643
Keyword(s) Food4Me study
Mediterranean diet
genetic risk
obesity
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
BODY-MASS INDEX
RANDOMIZED CONTROLLED-TRIAL
GENOME-WIDE ASSOCIATION
VIRGIN OLIVE OIL
CORONARY-HEART-DISEASE
WEIGHT-LOSS DIET
METABOLIC SYNDROME
PERSONALIZED NUTRITION
WAIST CIRCUMFERENCE
EUROPEAN ADULTS
Summary Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.
Language eng
DOI 10.3390/nu9101107
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109258

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.