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Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: a systematic review

van der Pligt, Paige, Willcox, Jane, Szymlek-Gay, Ewa A, Murray, Emily, Worsley, Francis and Daly, Robin M 2018, Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: a systematic review, Nutrients, vol. 10, no. 5, pp. 1-22, doi: 10.3390/nu10050640.

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Title Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: a systematic review
Author(s) van der Pligt, PaigeORCID iD for van der Pligt, Paige orcid.org/0000-0003-4391-9431
Willcox, Jane
Szymlek-Gay, Ewa AORCID iD for Szymlek-Gay, Ewa A orcid.org/0000-0002-6533-7945
Murray, Emily
Worsley, FrancisORCID iD for Worsley, Francis orcid.org/0000-0002-4635-6059
Daly, Robin MORCID iD for Daly, Robin M orcid.org/0000-0002-9897-1598
Journal name Nutrients
Volume number 10
Issue number 5
Start page 1
End page 22
Total pages 22
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-05-18
ISSN 2072-6643
Keyword(s) developing countries
gestational diabetes mellitus
low birth weight
maternal
neonatal
obstetric
pre-eclampsia
pregnancy
small for gestational age
vitamin D
Summary Pregnant women in Asia, the Middle East, Africa and Latin America are at risk of vitamin D deficiency (VDD) and prevalence throughout these regions are among the highest, globally. Maternal VDD has been associated with increased risk of a number of adverse maternal and neonatal health outcomes, yet research from developing countries is limited. We assessed the associations of maternal VDD during pregnancy with adverse health outcomes by synthesizing the literature from observational studies conducted in developing countries. Six electronic databases were searched for English-language studies published between 2000 and 2017. Thirteen studies from seven countries were included in the review. Prevalence of VDD ranged from 51.3% to 100%. Six studies assessed both maternal and neonatal outcomes, four studies assessed only maternal outcomes and three studies assessed only neonatal outcomes. Ten studies showed at least one significant association between VDD and adverse maternal and/or neonatal health outcomes including pre-eclampsia (n = 3), gestational diabetes mellitus (n = 1), postpartum depression (n = 1), emergency cesarean section delivery (n = 1), low birth weight babies (n = 4), small for gestational age (n = 2), stunting (n = 1). However most of these studies (n = 6) also showed no association with multiple health outcomes. Vitamin D assessment methods, criteria applied to define VDD, season and trimester in which studies were conducted varied considerably across studies. In conclusion, this study highlights the need to improve maternal vitamin D status in developing countries in an effort to support best maternal and child health outcomes across these regions. Future research should focus on more unified approaches to vitamin D assessment and preventative approaches that may be embedded into already existing antenatal care settings.
Language eng
DOI 10.3390/nu10050640
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, the authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109377

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.