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Development of transferrin receptor aptamers as drug delivery vehicles for the treatment of brain metastases

Macdonald, Joanna, Mandarano, Giovanni, Veedu, Rakesh N and Shigdar, Sarah 2018, Development of transferrin receptor aptamers as drug delivery vehicles for the treatment of brain metastases, Aptamers, vol. 2, pp. 15-27.

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Title Development of transferrin receptor aptamers as drug delivery vehicles for the treatment of brain metastases
Author(s) Macdonald, Joanna
Mandarano, GiovanniORCID iD for Mandarano, Giovanni orcid.org/0000-0002-8689-4070
Veedu, Rakesh N
Shigdar, Sarah
Journal name Aptamers
Volume number 2
Start page 15
End page 27
Total pages 13
Publisher International Society on Aptamers
Place of publication Oxford, Eng.
Publication date 2018
ISSN 2514-3247
Keyword(s) blood-brain-barrier
transferrin receptor
brain metastases
aptamers
bifunctional aptamer
drug delivery
Summary Affecting approximately up to 10-40% of all cancer patients, the prognosis for patients suffering from metastatic brain tumours is poor. Treatment of these metastatic tumours is greatly hindered by the presence of the blood brain barrier which restricts the overwhelming majority of small molecules from entering the brain. A novel approach to overcome this barrier is to target receptor mediated transport mechanisms present on the endothelial cell membranes, in particular the transferrin receptor. Given their specificity, safety profile and stability, nucleic acid-based therapeutics are ideal for this purpose. This review explores the development of bifunctional aptamers for the treatment of brain metastases.
Language eng
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109611

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.