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The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia

Horsington, Jacquelyn, Nfon, Charles, Bittner, Hilary, Durr, Peter A, Singanallur, Nagendrakumar, Alexandersen, Soren and Vosloo, Wilna 2018, The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia, PLoS one, vol. 13, no. 6, pp. 1-15, doi: 10.1371/journal.pone.0195302.

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Title The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia
Author(s) Horsington, Jacquelyn
Nfon, Charles
Bittner, Hilary
Durr, Peter A
Singanallur, Nagendrakumar
Alexandersen, SorenORCID iD for Alexandersen, Soren orcid.org/0000-0002-5039-3178
Vosloo, Wilna
Journal name PLoS one
Volume number 13
Issue number 6
Article ID e0195302
Start page 1
End page 15
Total pages 15
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2018-06-18
ISSN 1932-6203
Keyword(s) sheep
foot and mouth disease
livestock
vaccines
antibodies
veterinary diseases
enzyme-linked immunoassays
vaccination
immunisation
science & technology
multidisciplinary sciences
Summary Foot-and-mouth disease (FMD) is an acute, highly contagious viral disease of domestic and wild cloven-hoofed animals, caused by FMD virus (FMDV). An FMD outbreak can cause major production losses and have significant implications for trade. Vaccination can assist in controlling the disease, and emergency vaccination using high antigen payload vaccines (>6 PD50/dose) is considered an important control approach in the event of an outbreak. In recent years there has been a divergence of serotype A viruses in South East Asia (SEA) into several distinct genetic and antigenic clusters. Numerous variants were found to poorly match serotype A vaccines commonly included in international antigen banks. This study examined the ability of single vaccination with high-potency monovalent A22 IRQ vaccine to protect sheep following challenge with the A/VIT/15/2012 strain, just four days following vaccination. The vaccine proved effective at limiting clinical disease but did not prevent infection.
Language eng
DOI 10.1371/journal.pone.0195302
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Horsington et al.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109687

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.