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Aberrant neural activity in patients with bipolar depressive disorder distinguishing to the unipolar depressive disorder: a resting-state functional magnetic resonance imaging study

Qiu, Meihui, Zhang, Huifeng, Mellor, David, Shi, Jun, Wu, Chuangxin, Huang, Yueqi, Zhang, Jianye, Shen, Ting and Peng, Daihui 2018, Aberrant neural activity in patients with bipolar depressive disorder distinguishing to the unipolar depressive disorder: a resting-state functional magnetic resonance imaging study, Frontiers in psychiatry, vol. 9, pp. 1-9, doi: 10.3389/fpsyt.2018.00238.

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Title Aberrant neural activity in patients with bipolar depressive disorder distinguishing to the unipolar depressive disorder: a resting-state functional magnetic resonance imaging study
Author(s) Qiu, Meihui
Zhang, Huifeng
Mellor, DavidORCID iD for Mellor, David orcid.org/0000-0001-5007-5906
Shi, Jun
Wu, Chuangxin
Huang, Yueqi
Zhang, Jianye
Shen, Ting
Peng, Daihui
Journal name Frontiers in psychiatry
Volume number 9
Article ID 238
Start page 1
End page 9
Total pages 9
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2018-06
ISSN 1664-0640
Keyword(s) bipolar disorder
fractional amplitude of low frequency fluctuation
functional magnetic resonance imaging
resting-state
unipolar depressive disorder
science & technology
life sciences & biomedicine
psychiatry
Summary This study aims to explore the intrinsic patterns of spontaneous activity of bipolar depression (BD) patients by analyzing the fractional amplitude of low frequency fluctuation (fALFF) that help differentiate BD from unipolar depressive disorder(UD). Twenty eight patients with BD, 47 patients with UD and 29 healthy controls were enrolled to receive the resting-state functional magnetic resonance imaging (rs-fMRI) scans. The group differences of fALFF values were calculated among three groups. In addition, the correlations between the clinical variables and mfALFF values were estimated. The brain regions with activation discrepancies among three groups are located in precuneus, the left middle temporal gyrus (MTG) and left inferior parietal lobe (IPL) and lingual gyrus. Compared with HC group, BD group shows decreased fALFF in precuneus, the left IPL and increased fALFF in lingual gyrus remarkably; UD group shows significantly decreased fALFF in precuneus, the left MTG and the left IPL. On the contrast of patients with UD, patients with BD have significantly increased fALFF value in the left precuneus, the left MGT and lingual gyrus. Furthermore, a negative correlation is found between the mfALFF values in precuneus and the scores of cognitive impairment factor in the UD group. The similar pattern of intrinsic activity in PCC suggests depressive state-dependent change. The aberrant patterns of intrinsic activity in precuneus, the IPL and lingual gyrus might be provide quantitative nodes that help to conduct further study for better distinguishing between BD and UD.
Language eng
DOI 10.3389/fpsyt.2018.00238
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Qiu, Zhang, Mellor, Shi, Wu, Huang, Zhang, Shen and Peng
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109963

Document type: Journal Article
Collections: Faculty of Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.