Openly accessible

Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS

Bishop, David P., Hare, Dominic J., Fryer, Fred, Taudte, Regina V., Cardoso, Barbara R., Cole, Nerida and Doble, Philip A. 2015, Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS, Analyst, vol. 140, no. 8, pp. 2842-2846, doi: 10.1039/c4an02283a.

Attached Files
Name Description MIMEType Size Downloads
cardoso-determinationof-2015.pdf Published version application/pdf 990.86KB 2

Title Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS
Author(s) Bishop, David P.
Hare, Dominic J.
Fryer, Fred
Taudte, Regina V.
Cardoso, Barbara R.ORCID iD for Cardoso, Barbara R. orcid.org/0000-0002-6393-1377
Cole, Nerida
Doble, Philip A.
Journal name Analyst
Volume number 140
Issue number 8
Start page 2842
End page 2846
Total pages 5
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2015-04-21
ISSN 1364-5528
Keyword(s) Blood Chemical Analysis
Gadolinium
Humans
Mass Spectrometry
Oxygen
Selenium
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
PLASMA-MASS-SPECTROMETRY
CONTRAST AGENTS
COLLISION CELL
SPECTRAL INTERFERENCES
REFERENCE VALUES
CANCER
SELENOPROTEOME
CHILDREN
DISEASE
HEALTH
Summary Gadolinium (Gd)-based magnetic resonance imaging (MRI) contrasting agents interfere with the determination of selenium (Se) when analysed by single quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). This paper demonstrates that an ICP-triple quadrupole-MS (ICP-QQQ-MS) with oxygen mass shift overcomes Gd++ interference on Se+ and mitigates typically encountered matrix and spectral based interferences. Normal human serum was diluted in a solution containing isopropanol, EDTA, NH4OH and Triton X-100. Samples were unspiked (control) serum; serum spiked with 0.127 μmol L−1 Se or 127 μmol L−1 Gd; and serum spiked with both 0.127 μmol L−1 Se and 127 μmol L−1 Gd. Consideration of collision/reaction gases and conditions for interference mitigation included helium (He); a ‘low’ and ‘high’ hydrogen (H2) flow, and oxygen (O2). The instrument tune for O2 was optimised for effective elimination of interferences via a mass shift reaction of Se+ to SeO+. The ICP-QQQ-MS was capable of detecting trace (>9.34 nmol L−1) levels of Se in serum in the presence of Gd in our simulated post-MRI serum sample. The multi-tune capabilities of the ICP-QQQ-MS may be adapted to eliminate other specific isobaric interferences that cause false positive results in other analyses where the analyte is confounded by doubly charged and/or polyatomic species.
Language eng
DOI 10.1039/c4an02283a
Field of Research 0301 Analytical Chemistry
0399 Other Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Royal Society of Chemistry
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30109986

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 21 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 26 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Thu, 05 Jul 2018, 13:17:36 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.