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Tocotrienols and whey protein isolates substantially increase exercise endurance capacity in diet -induced obese male Sprague-Dawley rats

Betik, Andrew C, Aguila, Jay, McConell, Glenn K, McAinch, Andrew J and Mathai, Michael L 2016, Tocotrienols and whey protein isolates substantially increase exercise endurance capacity in diet -induced obese male Sprague-Dawley rats, PLoS one, vol. 11, no. 4, pp. 1-17, doi: 10.1371/journal.pone.0152562.

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Title Tocotrienols and whey protein isolates substantially increase exercise endurance capacity in diet -induced obese male Sprague-Dawley rats
Author(s) Betik, Andrew C
Aguila, Jay
McConell, Glenn K
McAinch, Andrew J
Mathai, Michael L
Journal name PLoS one
Volume number 11
Issue number 4
Article ID e0152562
Start page 1
End page 17
Total pages 17
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2016-04-08
ISSN 1932-6203
Keyword(s) glycogens
exercise
obesity
body weight
fats
diet
fatty acids
skeletal muscles
science & technology
Summary BACKGROUND AND AIMS: Obesity and impairments in metabolic health are associated with reductions in exercise capacity. Both whey protein isolates (WPIs) and vitamin E tocotrienols (TCTs) exert favorable effects on obesity-related metabolic parameters. This research sought to determine whether these supplements improved exercise capacity and increased glucose tolerance in diet-induced obese rats.

METHODS: Six week old male rats (n = 35) weighing 187 ± 32g were allocated to either: Control (n = 9), TCT (n = 9), WPI (n = 8) or TCT + WPI (n = 9) and placed on a high-fat diet (40% of energy from fat) for 10 weeks. Animals received 50mg/kg body weight and 8% of total energy intake per day of TCTs and/or WPIs respectively. Food intake, body composition, glucose tolerance, insulin sensitivity, exercise capacity, skeletal muscle glycogen content and oxidative enzyme activity were determined.

RESULTS: Both TCT and WPI groups ran >50% longer (2271 ± 185m and 2195 ± 265m respectively) than the Control group (1428 ± 139m) during the run to exhaustion test (P<0.05), TCT + WPI did not further improve exercise endurance (2068 ± 104m). WPIs increased the maximum in vitro activity of beta-hydroxyacyl-CoA in the soleus muscle (P<0.05 vs. Control) but not in the plantaris. Citrate synthase activity was not different between groups. Neither supplement had any effect on weight gain, adiposity, glucose tolerance or insulin sensitivity.

CONCLUSION: Ten weeks of both TCTs and WPIs increased exercise endurance by 50% in sedentary, diet-induced obese rats. These positive effects of TCTs and WPIs were independent of body weight, adiposity or glucose tolerance.
Language eng
DOI 10.1371/journal.pone.0152562
Field of Research MD Multidisciplinary
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2016, Betik et al.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110122

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.