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Intra- and inter-regional priming of ipsilateral human primary motor cortex with continuous theta burst stimulation does not induce consistent neuroplastic effects

Do, Michael, Kirkovski, Melissa, Davies, Charlotte B., Bekkali, Soukayna, Byrne, Linda K. and Enticott, Peter G. 2018, Intra- and inter-regional priming of ipsilateral human primary motor cortex with continuous theta burst stimulation does not induce consistent neuroplastic effects, Frontiers in human neuroscience, vol. 12, pp. 1-8, doi: 10.3389/fnhum.2018.00123.

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Title Intra- and inter-regional priming of ipsilateral human primary motor cortex with continuous theta burst stimulation does not induce consistent neuroplastic effects
Author(s) Do, MichaelORCID iD for Do, Michael orcid.org/0000-0002-1253-1007
Kirkovski, MelissaORCID iD for Kirkovski, Melissa orcid.org/0000-0003-3395-8525
Davies, Charlotte B.
Bekkali, Soukayna
Byrne, Linda K.ORCID iD for Byrne, Linda K. orcid.org/0000-0001-9055-0046
Enticott, Peter G.ORCID iD for Enticott, Peter G. orcid.org/0000-0002-6638-951X
Journal name Frontiers in human neuroscience
Volume number 12
Article ID 123
Start page 1
End page 8
Total pages 8
Publisher Frontiers
Place of publication Lausanne, Switzerland
Publication date 2018-03-29
ISSN 1662-5161
Keyword(s) corticospinal excitability
metaplasticity
motor cortex
neuroplasticity
theta burst stimulation
transcranial magnetic stimulation
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Neurosciences
Psychology
Neurosciences & Neurology
LTD-LIKE PLASTICITY
CORTICAL PLASTICITY
HOMEOSTATIC PLASTICITY
BRAIN-STIMULATION
PREMOTOR AREAS
FRONTAL-LOBE
EXCITABILITY
DEPRESSION
Summary Human responses to non-invasive brain stimulation (NIBS) techniques can be highly variable. Recently, priming protocols involving a conditioning round of NIBS applied to a target brain region prior to the application of a test protocol have shown promise in inducing more reliable effects. We investigated whether intra- or inter-regional priming of the left primary motor cortex (M1) using continuous theta burst stimulation (cTBS) can induce consistent, and reliable modulation of corticospinal excitability. Twenty healthy adults (six males) underwent four cTBS protocols. For intra-regional priming, cTBS was applied twice to the left M1 (M1-M1). For inter-regional M1 priming, cTBS was applied to the ipsilateral (left) dorsal premotor cortex (dPMC-M1), and ipsilateral (left) dorsolateral prefrontal cortex (DLPFC-M1). In the control condition, sham stimulation was applied to left M1, followed by active cTBS also applied to the left M1 (sham-M1). Each round of cTBS was separated by 10 min. Neuroplastic responses were indexed using motor evoked potentials (MEPs) elicited from the left M1 hand region, and measured from the contralateral first dorsal interosseous (right hand). MEP measurements were taken before the first round of cTBS priming, then immediately, 10, 20 and 30 min after the second test round of cTBS. The primary two-way repeated measures ANOVA revealed no significant differences in MEP responses across each condition (no main effects or interaction). Intra- and inter-regional priming of the left M1 using cTBS does not induce consistent neuroplastic effects. Further work is required to identify factors which contribute to such variability in human responses to NIBS.
Language eng
DOI 10.3389/fnhum.2018.00123
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Do, Kirkovski, Davies, Bekkali, Byrne and Enticott.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110129

Document type: Journal Article
Collections: School of Psychology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.