Openly accessible

Fibrous cap smooth muscle cells in atherosclerotic coronary arteries do not express pluripotent Stem cell markers

Sullivan, Melanie and Zulli, Anthony 2013, Fibrous cap smooth muscle cells in atherosclerotic coronary arteries do not express pluripotent Stem cell markers, Journal of angiology, vol. 2013, pp. 1-6, doi: 10.1155/2013/592815.

Attached Files
Name Description MIMEType Size Downloads
gunn-fibrouscapsmooth-2013.pdf Published version application/pdf 4.35MB 2

Title Fibrous cap smooth muscle cells in atherosclerotic coronary arteries do not express pluripotent Stem cell markers
Author(s) Sullivan, Melanie
Zulli, Anthony
Journal name Journal of angiology
Volume number 2013
Article ID 592815
Start page 1
End page 6
Total pages 7
Publisher Hindawi
Place of publication Cairo, Egypt
Publication date 2013
ISSN 2314-694X
Summary Rupture of the coronary artery fibrous cap is a common cause of myocardial infarction, and bone marrow derived cells could play a role in preventing plaque rupture. It is currently unknown whether smooth muscle cells within coronary artery fibrous cap formation are of mature phenotype. Objective. To characterize cells expressing bone marrow stem cells of embryonic type (ESC) markers in coronary artery fibrous cap formation. Design. New Zealand White rabbits were fed a diet supplemented with 0.5% cholesterol  +  1% methionine  +  5% peanut oil for 4 weeks and then a normal diet for 9 weeks. The left main coronary artery was excised from the heart, processed for paraffin and immunohistochemistry was performed by standard techniques. Results. Oct-4, SSEA 1, 3, and 4 were all present within in atherosclerotic plaque core, codistributed with RAM-11, and were sparingly found in the fibrous cap, but TRA-1-60 and TRA-1-81 positive cells were scarce. Core but not fibrous cap smooth muscle (SMC actin+) cells also showed codistribution with ESC markers. Conclusions. These results suggest that smooth muscle cells present in the fibrous cap do not express ESC markers, indicative of a mature cell.
Language eng
DOI 10.1155/2013/592815
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110154

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 10 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 09 Jul 2018, 11:22:52 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.