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The ADAMTS5 metzincin regulates zebrafish somite differentiation

Dancevic, Carolyn M, Gibert, Yann, Berger, Joachim, Smith, Adam D, Liongue, Clifford, Stupka, Nicole, Ward, Alister C and McCulloch, Daniel R 2018, The ADAMTS5 metzincin regulates zebrafish somite differentiation, International journal of molecular sciences, vol. 19, no. 3, pp. 1-12, doi: 10.3390/ijms19030766.

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Title The ADAMTS5 metzincin regulates zebrafish somite differentiation
Author(s) Dancevic, Carolyn M
Gibert, Yann
Berger, Joachim
Smith, Adam D
Liongue, CliffordORCID iD for Liongue, Clifford orcid.org/0000-0002-1646-4905
Stupka, NicoleORCID iD for Stupka, Nicole orcid.org/0000-0002-1000-1707
Ward, Alister CORCID iD for Ward, Alister C orcid.org/0000-0001-7945-7975
McCulloch, Daniel R
Journal name International journal of molecular sciences
Volume number 19
Issue number 3
Article ID 766
Start page 1
End page 12
Total pages 12
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-03-07
ISSN 1422-0067
1422-0067
Keyword(s) metalloproteinase
extracellular matrix
ADAMTS
somite
muscle
zebrafish
science & technology
life sciences & biomedicine
physical sciences
biochemistry & molecular biology
chemistry
Summary The ADAMTS5 metzincin, a secreted zinc-dependent metalloproteinase, modulates the extracellular matrix (ECM) during limb morphogenesis and other developmental processes. Here, the role of ADAMTS5 was investigated by knockdown of zebrafish adamts5 during embryogenesis. This revealed impaired Sonic Hedgehog (Shh) signaling during somite patterning and early myogenesis. Notably, synergistic regulation of myod expression by ADAMTS5 and Shh during somite differentiation was observed. These roles were not dependent upon the catalytic activity of ADAMTS5. These data identify a non-enzymatic function for ADAMTS5 in regulating an important cell signaling pathway that impacts on muscle development, with implications for musculoskeletal diseases in which ADAMTS5 and Shh have been associated.
Language eng
DOI 10.3390/ijms19030766
Field of Research 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, the authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110235

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.