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Microvascular retinopathy and angiographically-demonstrated coronary artery disease: a cross-sectional, observational study

Cheng, Lisa, Barlis, Peter, Gibson, Joel, Colville, Deb, Hutchinson, Anastasia, Gleeson, Geoff, Lamoureux, Ecosse, VanGaal, William and Savige, Judy 2018, Microvascular retinopathy and angiographically-demonstrated coronary artery disease: a cross-sectional, observational study, PLoS One, vol. 13, no. 5, pp. 1-12, doi: 10.1371/journal.pone.0192350.

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Title Microvascular retinopathy and angiographically-demonstrated coronary artery disease: a cross-sectional, observational study
Author(s) Cheng, Lisa
Barlis, Peter
Gibson, Joel
Colville, Deb
Hutchinson, AnastasiaORCID iD for Hutchinson, Anastasia orcid.org/0000-0002-0014-689X
Gleeson, Geoff
Lamoureux, Ecosse
VanGaal, William
Savige, Judy
Journal name PLoS One
Volume number 13
Issue number 5
Article ID e0192350
Start page 1
End page 12
Total pages 12
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2018
ISSN 1932-6203
Keyword(s) Adult
Aged
Aged, 80 and over
Coronary Angiography
Coronary Artery Disease
Coronary Vessels
Cross-Sectional Studies
Diabetic Retinopathy
Female
Humans
Male
Middle Aged
Retinal Diseases
Venules
Summary Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score. Subjects also underwent retinal photography (KOWA non-mydriatic camera, Japan), and their deidentified retinal images were graded for hypertensive microvascular retinopathy (Wong and Mitchell classification), vessel calibre using a computer-assisted method (IVAN, U Wisconsin), and diabetic retinopathy (modified Airlie House scheme) independently by a trained grader and an ophthalmologist. Retinal abnormalities were compared between subjects with high and low angiography scores using one way ANOVA, Chi squared and logistic regression analysis (StataCorp, Texas). Subjects had a mean age of 61 years (range 32–88), and included 101 males (70%). Seventeen (12%) had Leaman scores > 10.5, 46 (32%) had LAD stenosis, 13 (9%) had ≥ 3 arteries stenosed, and 20 (14%) had TIMI blush scores < 1. Twenty-six subjects (18%) had a retinal hemorrhage, and 115 (74%) a mild or moderate hypertensive retinopathy. Fifty-five (38%) had diabetes, and 24 (17%) a background (n = 20) or proliferative (n = 4) diabetic retinopathy. A retinal hemorrhage (p = 0.046), moderate microvascular retinopathy (p = 0.08) and proliferative diabetic retinopathy (p = 0.04) were all associated with a higher Leaman score. Venular calibre was increased with triple vessel disease (205.7 ± 21.6 μm, and 193.7 ± 22.3 μm in normals, p = 0.03). Diabetic retinopathy correlated with an increased TIMI blush score (p = 0.01). Retinal microvascular imaging warrants further evaluation in identifying the presence, extent and nature of coronary artery disease.
Language eng
DOI 10.1371/journal.pone.0192350
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110329

Document type: Journal Article
Collections: School of Nursing and Midwifery
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.