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In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules

Leng, Khoo Miew, Vijayarathna, Soundararajan, Jothy, Subramanion L, Sasidharan, Sreenivasan and Kanwar, Jagat R 2018, In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules, Future science OA, vol. 4, no. 2, pp. 1-20, doi: 10.4155/fsoa-2017-0085.

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Title In vitro and in vivo anticandidal activities of alginate-enclosed chitosan-calcium phosphate-loaded Fe-bovine lactoferrin nanocapsules
Author(s) Leng, Khoo Miew
Vijayarathna, Soundararajan
Jothy, Subramanion L
Sasidharan, Sreenivasan
Kanwar, Jagat RORCID iD for Kanwar, Jagat R orcid.org/0000-0003-3728-9568
Journal name Future science OA
Volume number 4
Issue number 2
Article ID FSO257
Start page 1
End page 20
Total pages 20
Publisher Future Science Group
Place of publication London, Eng.
Publication date 2018-02
ISSN 2056-5623
Keyword(s) antiyeast activity
Candida albicans
electron microscopy
histopathology
lactoferrin
nanocapsules
Summary Aim: To study the in vitro and in vivo anticandidal activity of nanocapsulated bovine lactoferrin. Materials & methods: In vitro and in vivo antimicrobial activities were conducted to study the anticandidal activities of nanocapsules (NCs).

Results: The NCs showed good anticandidal activities. The disruption of cell wall and cell membrane was noted via microscopy studies. The NCs changed the normal growth profile of Candida albicans. NCs reduced the colony forming unit in kidney and blood samples. Histopathological examination showed better cell structure and coordination compared with untreated mice kidney. NCs also enhanced the natural killing properties of C. albicans by epithelial cells.

Conclusion:
NCs have effective anticandidal properties and have the potential as a therapeutic agent against candidiasis.
Language eng
DOI 10.4155/fsoa-2017-0085
Copyright notice ©2017, KM Leng, S Vijayarathna, SL Johty, S Sasidharan & JR Kanwar
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110335

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.