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Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

Aldape, Kenneth, Amin, Samirkumar B, Ashley, David M, Barnholtz-Sloan, Jill S, Bates, Amanda J, Beroukhim, Rameen, Bock, Christoph, Brat, Daniel J, Claus, Elizabeth B, Costello, Joseph F, de Groot, John F, Finocchiaro, Gaetano, French, Pim J, Gan, Hui K, Griffith, Brent, Herold-Mende, Christel C, Horbinski, Craig, Iavarone, Antonio, Kalkanis, Steven N, Karabatsou, Konstantina, Khasraw, Mustafa, Kim, Hoon, Kouwenhoven, Mathilde CM, McDonald, Kerrie L, Miletic, Hrvoje, Nam, Do-Hyun, Ng, Ho Keung, Niclou, Simone P, Noushmehr, Houtan, Ormond, D Ryan, Poisson, Laila M, Reifenberger, Guido, Roncaroli, Federico, Sa, Jason K, Sillevis Smitt, Peter AE, Smits, Marion, Souza, Camila F, Tabatabai, Ghazaleh, Van Meir, Erwin G and Verhaak, Roel GW 2018, Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium, Neuro-oncology, vol. 20, no. 7, pp. 873-884, doi: 10.1093/neuonc/noy020.

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Title Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium
Author(s) Aldape, Kenneth
Amin, Samirkumar B
Ashley, David M
Barnholtz-Sloan, Jill S
Bates, Amanda J
Beroukhim, Rameen
Bock, Christoph
Brat, Daniel J
Claus, Elizabeth B
Costello, Joseph F
de Groot, John F
Finocchiaro, Gaetano
French, Pim J
Gan, Hui K
Griffith, Brent
Herold-Mende, Christel C
Horbinski, Craig
Iavarone, Antonio
Kalkanis, Steven N
Karabatsou, Konstantina
Khasraw, MustafaORCID iD for Khasraw, Mustafa orcid.org/0000-0003-3249-9849
Kim, Hoon
Kouwenhoven, Mathilde CM
McDonald, Kerrie L
Miletic, Hrvoje
Nam, Do-Hyun
Ng, Ho Keung
Niclou, Simone P
Noushmehr, Houtan
Ormond, D Ryan
Poisson, Laila M
Reifenberger, Guido
Roncaroli, Federico
Sa, Jason K
Sillevis Smitt, Peter AE
Smits, Marion
Souza, Camila F
Tabatabai, Ghazaleh
Van Meir, Erwin G
Verhaak, Roel GW
Journal name Neuro-oncology
Volume number 20
Issue number 7
Start page 873
End page 884
Total pages 12
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2018-07
ISSN 1523-5866
Keyword(s) characterization
evolution
glioma
sequencing
subtypes
science & technology
life sciences & biomedicine
oncology
clinical neurology
neurosciences & neurology
Summary Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.
Language eng
DOI 10.1093/neuonc/noy020
Field of Research 1109 Neurosciences
1112 Oncology And Carcinogenesis
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110409

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.