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Onset symptoms, tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset

Tao, Chunrong, Simpson Jr, Steve, Taylor, Bruce V., Blizzard, Leigh, Lucas, Robyn M., Ponsonby, Anne-Louise, Broadley, Simon, van der Mei, Ingrid, AusLong/Ausimmune Investigators Group and Shaw, Cameron 2018, Onset symptoms, tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset, Frontiers in Neurology, vol. 9, doi: 10.3389/fneur.2018.00418.

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Title Onset symptoms, tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset
Author(s) Tao, Chunrong
Simpson Jr, Steve
Taylor, Bruce V.
Blizzard, Leigh
Lucas, Robyn M.
Ponsonby, Anne-Louise
Broadley, Simon
van der Mei, Ingrid
AusLong/Ausimmune Investigators Group
Shaw, CameronORCID iD for Shaw, Cameron orcid.org/0000-0002-1966-5200
Journal name Frontiers in Neurology
Volume number 9
Article ID 418
Total pages 10
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2018-06-08
ISSN 1664-2295
Keyword(s) first demyelinating event
age at symptom onset
smoking
offspring number
marijuana
sclerosis
Summary Background: Age at symptom onset (ASO) is a prognostic factor that could affect the accrual of disability in multiple sclerosis (MS) patients. Some factors are known to influence the risk of multiple sclerosis (MS), but their influence on the ASO is less well-investigated.

Objective: Examine the associations between known or emerging MS risk factors and ASO. Methods: This was a multicenter study, incident cases (n = 279) with first clinical diagnosis of demyelinating event aged 18-59 years recruited at four Australian centres (latitudes 27°-43°S), from 1 November 2003 to 31 December 2006. Environmental/behavioral variables and initial symptoms were recorded at baseline interview. Linear regression was used to assess the association between risk factors and ASO.

Results: Five factors were significantly associated with ASO: a history of tobacco smoking was associated with 3.05-years later ASO (p = 0.002); a history of marijuana use was associated with 6.03-years earlier ASO (p < 0.001); progressive-onset cases had 5.61-years later ASO (p = 0.001); an initial presentation of bowel & bladder and cerebral dysfunctional were associated with 3.39 (p = 0.017) and 4.37-years (p = 0.006) later ASO, respectively. Other factors, including sex, offspring number, latitude of study site, history of infectious mononucleosis, HLA-DR15 & HLA-A2 genotype, 25(OH)D levels, and ultraviolet radiation exposure were not associated with ASO. Including all five significant variables into one model explained 12% of the total variance in ASO.

Conclusion: We found a novel association between a history of tobacco smoking and later onset, whereas marijuana use was associated with earlier onset. Behavioral factors seem important drivers of MS onset timing although much of the variance remains unexplained.
Language eng
DOI 10.3389/fneur.2018.00418
Field of Research 1109 Neurosciences
1103 Clinical Sciences
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110473

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.