Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery

Cho, Hea-Young, Kang, Jun-Hyuk, Ngo, Lien, Tran, Ha Lien Phuong and Lee, Yong-Bok 2016, Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery, Journal of nanomaterials, vol. 2016, pp. 1-14, doi: 10.1155/2016/3642418.

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Title Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery
Author(s) Cho, Hea-Young
Kang, Jun-Hyuk
Ngo, Lien
Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Lee, Yong-Bok
Journal name Journal of nanomaterials
Volume number 2016
Article ID 3642418
Start page 1
End page 14
Total pages 14
Publisher Hindawi Publishing Corporation
Place of publication Cairo, Egypt
Publication date 2016
ISSN 1687-4110
1687-4129
Keyword(s) solid-self-emulsifying drug delivery system (S-SEDDS)
paclitaxel (Ptx)
bioavailability (BA)
lymphatic delivery
Summary Solid-self-emulsifying drug delivery system (S-SEDDS) of paclitaxel (Ptx) was developed by the spray drying method with the purpose of improving the low bioavailability (BA) of Ptx. 10% oil (ethyl oleate), 80% surfactant mixture (Tween 80: Carbitol, 90: 10, w/w), and 10% cosolvent (PEG 400) were chosen according to their solubilizing capacity. The mean droplet size, zeta potential, and encapsulation efficiency of the prepared S-SEDDS were 16.9 ± 1.53 nm, 12.5 ± 1.66 mV, and 56.2 ± 8.1%, respectively. In the S-SEDDS, Ptx presents in the form of molecular dispersion in the emulsions or is distributed in an amorphous state or crystalline with very small size. The prepared S-SEDDS formulation showed 70 and 75% dissolution in 60 and 30 min in dissolution medium pH 1.2 and 6.8, respectively. Significant increase (P ≤ 0.05) in the peak concentration (C m a x), the area under the curve (A U C 0 - ∞), and the lymphatic targeting efficiency of Ptx was observed after the oral administration of the Ptx-loaded S-SEDDS to rats (20 mg/kg as Ptx). Our research suggests the prepared Ptx-loaded S-SEDDS can be a good candidate for the enhancement of BA and targeting drug delivery to the lymphatic system of Ptx.
Language eng
DOI 10.1155/2016/3642418
Copyright notice ©2016, Hea-Young Cho et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110504

Document type: Journal Article
Collections: School of Medicine
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