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Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery

Cho, Hea-Young, Kang, Jun-Hyuk, Ngo, Lien, Tran, Phuong and Lee, Yong-Bok 2016, Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery, Journal of nanomaterials, vol. 2016, pp. 1-14, doi: 10.1155/2016/3642418.

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Title Preparation and evaluation of solid-self-emulsifying drug delivery system containing paclitaxel for lymphatic delivery
Author(s) Cho, Hea-Young
Kang, Jun-Hyuk
Ngo, Lien
Tran, PhuongORCID iD for Tran, Phuong orcid.org/0000-0001-8463-7516
Lee, Yong-Bok
Journal name Journal of nanomaterials
Volume number 2016
Article ID 3642418
Start page 1
End page 14
Total pages 14
Publisher Hindawi Publishing Corporation
Place of publication Cairo, Egypt
Publication date 2016
ISSN 1687-4110
1687-4129
Keyword(s) solid-self-emulsifying drug delivery system (S-SEDDS)
paclitaxel (Ptx)
bioavailability (BA)
lymphatic delivery
Summary Solid-self-emulsifying drug delivery system (S-SEDDS) of paclitaxel (Ptx) was developed by the spray drying method with the purpose of improving the low bioavailability (BA) of Ptx. 10% oil (ethyl oleate), 80% surfactant mixture (Tween 80: Carbitol, 90: 10, w/w), and 10% cosolvent (PEG 400) were chosen according to their solubilizing capacity. The mean droplet size, zeta potential, and encapsulation efficiency of the prepared S-SEDDS were 16.9 ± 1.53 nm, 12.5 ± 1.66 mV, and 56.2 ± 8.1%, respectively. In the S-SEDDS, Ptx presents in the form of molecular dispersion in the emulsions or is distributed in an amorphous state or crystalline with very small size. The prepared S-SEDDS formulation showed 70 and 75% dissolution in 60 and 30 min in dissolution medium pH 1.2 and 6.8, respectively. Significant increase (P ≤ 0.05) in the peak concentration (C m a x), the area under the curve (A U C 0 - ∞), and the lymphatic targeting efficiency of Ptx was observed after the oral administration of the Ptx-loaded S-SEDDS to rats (20 mg/kg as Ptx). Our research suggests the prepared Ptx-loaded S-SEDDS can be a good candidate for the enhancement of BA and targeting drug delivery to the lymphatic system of Ptx.
Language eng
DOI 10.1155/2016/3642418
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Hea-Young Cho et al.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110504

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.