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The effect of ginger (Zingiber officinale) on platelet aggregation: a systematic literature review

Marx, Wolfgang, McKavanagh, Daniel, McCarthy, Alexandra L., Bird, Robert, Ried, Karin, Chan, Alexandre and Isenring, Liz 2015, The effect of ginger (Zingiber officinale) on platelet aggregation: a systematic literature review, PLoS One, vol. 10, no. 10, pp. e0141119, doi: 10.1371/journal.pone.0141119.

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Title The effect of ginger (Zingiber officinale) on platelet aggregation: a systematic literature review
Author(s) Marx, WolfgangORCID iD for Marx, Wolfgang orcid.org/0000-0002-8556-8230
McKavanagh, Daniel
McCarthy, Alexandra L.
Bird, Robert
Ried, Karin
Chan, Alexandre
Isenring, Liz
Journal name PLoS One
Volume number 10
Issue number 10
Start page e0141119
Total pages 13
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2015-10-21
ISSN 1932-6203
Keyword(s) Adolescent
Adult
Clinical Trials as Topic
Female
Ginger
Humans
Male
Phytotherapy
Plant Extracts
Platelet Aggregation
Platelet Function Tests
Young Adult
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ALTERNATIVE MEDICINE
ANTIPLATELET AGGREGATION
THROMBOXANE PRODUCTION
DIETARY-SUPPLEMENTS
WARFARIN
COMPLEMENTARY
CONSTITUENTS
NAUSEA
METAANALYSIS
CONSUMPTION
Summary BACKGROUND: The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date.

METHODS: Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome.

RESULTS: Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings.

DISCUSSION: Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases).

CONCLUSION: The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.
Language eng
DOI 10.1371/journal.pone.0141119
Field of Research MD Multidisciplinary
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110569

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.