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Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009

Dellagi, K, Rollot, O, Temmam, S, Salez, N, Guernier, Vanina, Pascalis, H, Gerardin, P, Fianu, A, Lapidus, N, Naty, N, Tortosa, P, Boussaid, K, Jaffar-Banjee, M-C, Filleul, L, Flahault, A, Carrat, F, Favier, F and de Lamballerie, X 2011, Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009, PloS one, vol. 6, no. 9, pp. 1-10, doi: 10.1371/journal.pone.0025738.

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Title Pandemic Influenza Due to pH1N1/2009 Virus: Estimation of Infection Burden in Reunion Island through a Prospective Serosurvey, Austral Winter 2009
Author(s) Dellagi, K
Rollot, O
Temmam, S
Salez, N
Guernier, VaninaORCID iD for Guernier, Vanina orcid.org/0000-0002-0960-3874
Pascalis, H
Gerardin, P
Fianu, A
Lapidus, N
Naty, N
Tortosa, P
Boussaid, K
Jaffar-Banjee, M-C
Filleul, L
Flahault, A
Carrat, F
Favier, F
de Lamballerie, X
Journal name PloS one
Volume number 6
Issue number 9
Article ID e25738
Start page 1
End page 10
Total pages 10
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2011-09-29
ISSN 1932-6203
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
A H1N1 VIRUS
ANTIBODY-RESPONSES
RISK-FACTORS
SEROCONVERSION
SURVEILLANCE
POPULATION
EMERGENCE
SINGAPORE
VACCINE
Summary Background
To date, there is little information that reflects the true extent of spread of the pH1N1/2009v influenza pandemic at the community level as infection often results in mild or no clinical symptoms. This study aimed at assessing through a prospective study, the attack rate of pH1N1/2009 virus in Reunion Island and risk factors of infection, during the 2009 season.

Methodology/Principal Findings
A serosurvey was conducted during the 2009 austral winter, in the frame of a prospective population study. Pairs of sera were collected from 1687 individuals belonging to 772 households, during and after passage of the pandemic wave. Antibodies to pH1N1/2009v were titered using the hemagglutination inhibition assay (HIA) with titers ≥1/40 being considered positive. Seroprevalence during the first two weeks of detection of pH1N1/2009v in Reunion Island was 29.8% in people under 20 years of age, 35.6% in adults (20–59 years) and 73.3% in the elderly (≥60 years) (P<0.0001). Baseline corrected cumulative incidence rates, were 42.9%, 13.9% and 0% in these age groups respectively (P<0.0001). A significant decline in antibody titers occurred soon after the passage of the epidemic wave. Seroconversion rates to pH1N1/2009 correlated negatively with age: 63.2%, 39.4% and 16.7%, in each age group respectively (P<0.0001). Seroconversion occurred in 65.2% of individuals who were seronegative at inclusion compared to 6.8% in those who were initially seropositive.

Conclusions
Seroincidence of pH1N1/2009v infection was three times that estimated from clinical surveillance, indicating that almost two thirds of infections occurring at the community level have escaped medical detection. People under 20 years of age were the most affected group. Pre-epidemic titers ≥1/40 prevented seroconversion and are likely protective against infection. A concern was raised about the long term stability of the antibody responses.
Language eng
DOI 10.1371/journal.pone.0025738
Field of Research MD Multidisciplinary
HERDC Research category CN.1 Other journal article
Copyright notice ©2011, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110642

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.