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Biogeography of Leptospira in wild animal communities inhabiting the insular ecosystem of the western Indian Ocean islands and neighboring Africa

Dietrich, Muriel, Gomard, Yann, Lagadec, Erwan, Ramasindrazana, Beza, Le Minter, Gildas, Guernier, Vanina, Benlali, Aude, Rocamora, Gerard, Markotter, Wanda, Goodman, Steven M., Dellagi, Koussay and Tortosa, Pablo 2018, Biogeography of Leptospira in wild animal communities inhabiting the insular ecosystem of the western Indian Ocean islands and neighboring Africa, Emerging microbes and infections, vol. 7, no. 1, pp. 1-12, doi: 10.1038/s41426-018-0059-4.

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Title Biogeography of Leptospira in wild animal communities inhabiting the insular ecosystem of the western Indian Ocean islands and neighboring Africa
Author(s) Dietrich, Muriel
Gomard, Yann
Lagadec, Erwan
Ramasindrazana, Beza
Le Minter, Gildas
Guernier, VaninaORCID iD for Guernier, Vanina orcid.org/0000-0002-0960-3874
Benlali, Aude
Rocamora, Gerard
Markotter, Wanda
Goodman, Steven M.
Dellagi, Koussay
Tortosa, Pablo
Journal name Emerging microbes and infections
Volume number 7
Issue number 1
Article ID 57
Start page 1
End page 12
Total pages 12
Publisher Nature
Place of publication London, Eng.
Publication date 2018-04-04
ISSN 2222-1751
Keyword(s) Africa
Animals
Animals, Wild
Ecosystem
Genetic Variation
Genotype
Indian Ocean Islands
Islands
Leptospira
Leptospirosis
Mammals
Phylogeny
Science & Technology
Life Sciences & Biomedicine
Immunology
Microbiology
PATHOGENIC LEPTOSPIRA
REUNION ISLAND
MADAGASCAR
TRANSMISSION
HUMANS
BATS
BIODIVERSITY
COMOROS
HISTORY
Summary Understanding the processes driving parasite assemblages is particularly important in the context of zoonotic infectious diseases. Leptospirosis is a widespread zoonotic bacterial infection caused by pathogenic species of the genus Leptospira. Despite a wide range of animal hosts, information is still lacking on the factors shaping Leptospira diversity in wild animal communities, especially in regions, such as tropical insular ecosystems, with high host species richness and complex biogeographical patterns. Using a large dataset (34 mammal species) and a multilocus approach at a regional scale, we analyzed the role of both host species diversity and geography in Leptospira genetic diversity in terrestrial small mammals (rodents, tenrecs, and shrews) and bats from 10 different islands/countries in the western Indian Ocean (WIO) and neighboring Africa. At least four Leptospira spp. (L. interrogans, L. borgpetersenii, L. kirschneri, and L. mayottensis) and several yet-unidentified genetic clades contributed to a remarkable regional Leptospira diversity, which was generally related to the local occurrence of the host species rather than the geography. In addition, the genetic structure patterns varied between Leptospira spp., suggesting different evolutionary histories in the region, which might reflect both in situ diversification of native mammals (for L. borgpetersenii) and the more recent introduction of non-native host species (for L. interrogans). Our data also suggested that host shifts occurred between bats and rodents, but further investigations are needed to determine how host ecology may influence these events.
Language eng
DOI 10.1038/s41426-018-0059-4
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110646

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.