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Theory of mind mediates the prospective relationship between abnormal social brain network morphology and chronic behavior problems after pediatric traumatic brain injury

Ryan, Nicholas P., Catroppa, Cathy, Beare, Richard, Silk, Timothy J., Crossley, Louise, Beauchamp, Miriam H., Yeates, Keith Owen and Anderson, Vicki A. 2016, Theory of mind mediates the prospective relationship between abnormal social brain network morphology and chronic behavior problems after pediatric traumatic brain injury, Social cognitive and affective neuroscience, vol. 11, no. 4, pp. 683-692, doi: 10.1093/scan/nsw007.

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Title Theory of mind mediates the prospective relationship between abnormal social brain network morphology and chronic behavior problems after pediatric traumatic brain injury
Author(s) Ryan, Nicholas P.ORCID iD for Ryan, Nicholas P. orcid.org/0000-0002-0878-8889
Catroppa, Cathy
Beare, Richard
Silk, Timothy J.
Crossley, Louise
Beauchamp, Miriam H.
Yeates, Keith Owen
Anderson, Vicki A.
Journal name Social cognitive and affective neuroscience
Volume number 11
Issue number 4
Start page 683
End page 692
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2016-04
ISSN 1749-5024
1749-5024
Keyword(s) brain injuries
childhood
magnetic resonance imaging
social cognition
theory of mind
Adolescent
Brain
Brain Damage, Chronic
Brain Injuries, Traumatic
Child
Child Behavior Disorders
Female
Follow-Up Studies
Gray Matter
Humans
Imaging, Three-Dimensional
Male
Nerve Net
Prospective Studies
Social Behavior
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Neurosciences
Psychology
Psychology, Experimental
Neurosciences & Neurology
SUPERIOR TEMPORAL SULCUS
YOUNG-ADULT SURVIVORS
NEURAL BASIS
EXTERNALIZING BEHAVIOR
CORPUS-CALLOSUM
AXONAL INJURY
BIRTH COHORT
CHILDREN
MODERATE
PREDICTORS
Summary Childhood and adolescence coincide with rapid maturation and synaptic reorganization of distributed neural networks that underlie complex cognitive-affective behaviors. These regions, referred to collectively as the ‘social brain network’ (SBN) are commonly vulnerable to disruption from pediatric traumatic brain injury (TBI); however, the mechanisms that link morphological changes in the SBN to behavior problems in this population remain unclear. In 98 children and adolescents with mild to severe TBI, we acquired 3D T1-weighted MRIs at 2–8 weeks post-injury. For comparison, 33 typically developing controls of similar age, sex and education were scanned. All participants were assessed on measures of Theory of Mind (ToM) at 6 months post-injury and parents provided ratings of behavior problems at 24-months post-injury. Severe TBI was associated with volumetric reductions in the overall SBN package, as well as regional gray matter structural change in multiple component regions of the SBN. When compared with TD controls and children with milder injuries, the severe TBI group had significantly poorer ToM, which was associated with more frequent behavior problems and abnormal SBN morphology. Mediation analysis indicated that impaired theory of mind mediated the prospective relationship between abnormal SBN morphology and more frequent chronic behavior problems. Our findings suggest that sub-acute alterations in SBN morphology indirectly contribute to long-term behavior problems via their influence on ToM. Volumetric change in the SBN and its putative hub regions may represent useful imaging biomarkers for prediction of post-acute social cognitive impairment, which may in turn elevate risk for chronic behavior problems.
Language eng
DOI 10.1093/scan/nsw007
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Science
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110695

Document type: Journal Article
Collections: School of Psychology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.