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Genetic and environmental influences on height from infancy to early adulthood: an individual-based pooled analysis of 45 twin cohorts

Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob v.B., Möller, Sören, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, José Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang and Craig, Jeffrey M. 2016, Genetic and environmental influences on height from infancy to early adulthood: an individual-based pooled analysis of 45 twin cohorts, Scientific Reports, vol. 6, doi: 10.1038/srep28496.

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Title Genetic and environmental influences on height from infancy to early adulthood: an individual-based pooled analysis of 45 twin cohorts
Author(s) Jelenkovic, Aline
Sund, Reijo
Hur, Yoon-Mi
Yokoyama, Yoshie
Hjelmborg, Jacob v.B.
Möller, Sören
Honda, Chika
Magnusson, Patrik K. E.
Pedersen, Nancy L.
Ooki, Syuichi
Aaltonen, Sari
Stazi, Maria A.
Fagnani, Corrado
D'Ippolito, Cristina
Freitas, Duarte L.
Maia, José Antonio
Ji, Fuling
Ning, Feng
Pang, Zengchang
Craig, Jeffrey M.ORCID iD for Craig, Jeffrey M. orcid.org/0000-0003-3979-7849
Journal name Scientific Reports
Volume number 6
Article ID 28496
Total pages 13
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2016-06-23
ISSN 2045-2322
2045-2322
Keyword(s) Adolescent
Australia
Body Height
Child
Child, Preschool
Cohort Studies
Environment
Europe
Far East
Female
Gene-Environment Interaction
Genetic Variation
Humans
Infant
Male
North America
Twins, Dizygotic
Twins, Monozygotic
Young Adult
Summary Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
Language eng
DOI 10.1038/srep28496
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30110778

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.