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Electrospun fibrous scaffolds for small-diameter blood vessels: a review

Awad, Nasser K., Niu, Haitao, Ali, Usman, Morsi, Yosry S. and Lin, Tong 2018, Electrospun fibrous scaffolds for small-diameter blood vessels: a review, Membranes, vol. 8, no. 1, doi: 10.3390/membranes8010015.

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Title Electrospun fibrous scaffolds for small-diameter blood vessels: a review
Author(s) Awad, Nasser K.
Niu, HaitaoORCID iD for Niu, Haitao orcid.org/0000-0002-8442-7444
Ali, Usman
Morsi, Yosry S.
Lin, TongORCID iD for Lin, Tong orcid.org/0000-0002-1003-0671
Journal name Membranes
Volume number 8
Issue number 1
Article ID 15
Total pages 26
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-03-06
ISSN 2077-0375
Keyword(s) SDBVs
anti-thrombogenic agents
electrospinning
fibrous scaffold
thrombosis
Summary Small-diameter blood vessels (SDBVs) are still a challenging task to prepare due to the occurrence of thrombosis formation, intimal hyperplasia, and aneurysmal dilation. Electrospinning technique, as a promising tissue engineering approach, can fabricate polymer fibrous scaffolds that satisfy requirements on the construction of extracellular matrix (ECM) of native blood vessel and promote the adhesion, proliferation, and growth of cells. In this review, we summarize the polymers that are deployed for the fabrication of SDBVs and classify them into three categories, synthetic polymers, natural polymers, and hybrid polymers. Furthermore, the biomechanical properties and the biological activities of the electrospun SBVs including anti-thrombogenic ability and cell response are discussed. Polymer blends seem to be a strategic way to fabricate SDBVs because it combines both suitable biomechanical properties coming from synthetic polymers and favorable sites to cell attachment coming from natural polymers.
Language eng
DOI 10.3390/membranes8010015
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30111150

Document type: Journal Article
Collections: Institute for Frontier Materials
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.