Short oxygen plasma treatment leading to long-term hydrophilicity of conductive PCL-PPy nanofiber scaffolds

Shafei, Sajjad, Foroughi, Javad, Chen, Zhiqiang, Wong, Cynthia S and Naebe, Minoo 2017, Short oxygen plasma treatment leading to long-term hydrophilicity of conductive PCL-PPy nanofiber scaffolds, Polymers, vol. 9, no. 11, pp. 1-14, doi: 10.3390/polym9110614.

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Title Short oxygen plasma treatment leading to long-term hydrophilicity of conductive PCL-PPy nanofiber scaffolds
Author(s) Shafei, Sajjad
Foroughi, Javad
Chen, ZhiqiangORCID iD for Chen, Zhiqiang
Wong, Cynthia S
Naebe, MinooORCID iD for Naebe, Minoo
Journal name Polymers
Volume number 9
Issue number 11
Article ID 614
Start page 1
End page 14
Total pages 14
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2017
ISSN 2073-4360
Keyword(s) durable plasma treatment
conductive scaffold
hydrophilic PPy-coated PCL fibers
nanofiber scaffolds
tissue engineering
Summary Electrically conductive scaffolds are of significant interest in tissue regeneration. However, the chemistry of the existing scaffolds usually lacks the bioactive features for effective interaction with cells. In this study, poly(ε-caprolactone) was electrospun into aligned nanofibers with 0.58 μm average diameter. Electrospinning was followed by polypyrrole coating on the surface of the fibers, which resulted in 48 kΩ/sq surface resistivity. An oxygen plasma treatment was conducted to change the hydrophobic surface of the fiber mats into a hydrophilic substrate. The water contact angle was reduced from 136° to 0°, and this change remained on the surface of the material even after one year. An indirect cytotoxicity test was conducted, which showed cytocompatibility of the fibrous scaffolds. To measure the cell growth on samples, fibroblast cells were cultured on fibers for 7 days. The cell distribution and density were observed and calculated based on confocal images taken of the cell culture experiment. The number of cells on the plasma-treated sample was more than double than that of sample without plasma treatment. The long-lasting hydrophilicity of the plasma treated fibers with conductive coating is the significant contribution of this work for regeneration of electrically excitable tissues.
Language eng
DOI 10.3390/polym9110614
Indigenous content off
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2017, the authors
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