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Regional cerebrovascular reactivity and cognitive performance in healthy aging

Catchlove, Sarah J, Parrish, Todd B, Chen, Yufen, Macpherson, Helen, Hughes, Matthew E and Pipingas, Andrew 2018, Regional cerebrovascular reactivity and cognitive performance in healthy aging, Journal of experimental neuroscience, vol. 12, pp. 1-11, doi: 10.1177/1179069518785151.

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Title Regional cerebrovascular reactivity and cognitive performance in healthy aging
Author(s) Catchlove, Sarah J
Parrish, Todd B
Chen, Yufen
Macpherson, HelenORCID iD for Macpherson, Helen orcid.org/0000-0002-3603-9359
Hughes, Matthew E
Pipingas, Andrew
Journal name Journal of experimental neuroscience
Volume number 12
Start page 1
End page 11
Total pages 11
Publisher SAGE Publications
Place of publication London, Eng.
Publication date 2018-01-01
ISSN 1179-0695
Keyword(s) cerebrovascular reactivity
cognition
healthy aging
magnetic resonance imaging (MRI)
memory
Summary Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in cognitively healthy people. These findings may inform other areas of research concerned with vaso-protective approaches for prevention or treatment of neurocognitive decline.
Language eng
DOI 10.1177/1179069518785151
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30111659

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.