Zebrafish as a model to evaluate nanoparticle toxicity

Haque, Md Enamul and Ward, Alister C 2018, Zebrafish as a model to evaluate nanoparticle toxicity, Nanomaterials, vol. 8, no. 7, pp. 1-18, doi: 10.3390/nano8070561.

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Title Zebrafish as a model to evaluate nanoparticle toxicity
Author(s) Haque, Md EnamulORCID iD for Haque, Md Enamul orcid.org/0000-0002-8893-2181
Ward, Alister CORCID iD for Ward, Alister C orcid.org/0000-0001-7945-7975
Journal name Nanomaterials
Volume number 8
Issue number 7
Article ID 561
Start page 1
End page 18
Total pages 18
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-07-23
ISSN 2079-4991
Keyword(s) zebrafish
nanoparticles
nanotoxicity
biocompatibility
science & technology
technology
nanoscience & nanotechnology
materials science
Summary Nanoparticles are increasingly being developed for in vivo use, from targeted drug delivery to diagnostics, where they have enormous potential, while they are also being used for a variety of applications that can result in environmental exposure for humans. Understanding how specific nanoparticles interact with cells and cell systems is essential to gauge their safety with respect to either clinical or environmental exposure. Zebrafish is being increasingly employed as a model to evaluate nanoparticle biocompatibility. This review describes this model and how it can be used to assess nanoparticle toxicity at multiple levels, including mortality, teratogenicity, immunotoxicity, genotoxicity, as well as alterations in reproduction, behavior and a range of other physiological readouts. This review also provides an overview of studies using this model to assess the toxicity of metal, metal oxide and carbon-based nanoparticles. It is anticipated that this information will inform research aimed at developing biocompatible nanoparticles for a range of uses.
Language eng
DOI 10.3390/nano8070561
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, the authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112040

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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